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Association between temporal muscle thickness and clinical outcomes in patients with newly diagnosed glioblastoma

  • Original Article – Clinical Oncology
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Temporal muscle thickness (TMT) has been suggested as a novel biomarker that can represent sarcopenia in head and neck malignancies. This study investigated the association of TMT with clinical outcomes in patients with newly diagnosed glioblastoma (GBM).

Methods

Using electronic medical records, all GBM patients between 2008 and 2018 at Seoul St. Mary’s Hospital were reviewed. Total 177 patients met our eligibility criteria.

Results

The thinner group who had TMT less than the median showed shorter overall survival (OS) and progression-free survival (PFS) than the thicker group who had TMT more than median (OS; 11.0 versus 18.0 months, p < 0.001, and PFS; 6.0 versus 11.0 months, p < 0.001). In the multivariate analysis, the thinner group had negative associations with OS and PFS (OS; HR 2.63 (1.34–2.63), p < 0.001, and PFS; HR 2.21 (1.34–2.50), p = 0.002). We also performed propensity score matching between the thinner and thicker groups to minimize the potential bias. The thinner group showed shorter OS and PFS (OS; 13.5 versus 19.0 months, p = 0.006, and PFS; 6.5 versus 9.0 months, p = 0.028) and had negative associations with OS and PFS than the thicker group (OS; HR 1.90 (1.19–3.03), p = 0.008, and PFS; HR 1.70 (1.07–2.70), p = 0.026) in matched patients.

Conclusion

Our findings suggest that TMT can be a useful prognostic biomarker for clinical outcomes in GBM patients. Further preclinical and clinical studies could help elucidate this association of sarcopenia with clinical outcomes in GBM patients.

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Data availability

All data supporting the findings presented in this manuscript are available upon reasonable request directly to the corresponding author.

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Funding

This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science and ICT at South Korea (NRF- 2020M3A9E8024875).

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Authors and Affiliations

  1. Department of Neurosurgery, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, 222 Banpodae-ro, Seocho-gu, Seoul, 06591, South Korea

    Geon An, Stephen Ahn, Jae-Sung Park, Sin- Soo Jeun & Yong- Kil Hong

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  1. Geon An
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  2. Stephen Ahn
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  3. Jae-Sung Park
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  4. Sin- Soo Jeun
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Contributions

Conceptualization: SA. Methodology, data curation: GA, SA. Writing—original draft preparation: GA, SA. Writing—review and editing: J-SP, S-SJ, Y-KH. Funding acquisition: SA.

Corresponding author

Correspondence to Stephen Ahn.

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Conflict of interest

The authors declare no conflicts of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Ethics approval

This study has been approved by the Institutional Review Board of Seoul St. Mary’s Hospital.

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An, G., Ahn, S., Park, JS. et al. Association between temporal muscle thickness and clinical outcomes in patients with newly diagnosed glioblastoma. J Cancer Res Clin Oncol 147, 901–909 (2021). https://doi.org/10.1007/s00432-020-03386-5

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  • DOI: https://doi.org/10.1007/s00432-020-03386-5

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