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RETRACTED ARTICLE: Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery

  • Original Paper
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Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

This article was retracted on 20 January 2015

A Letter to the Editor to this article was published on 13 February 2014

A Letter to the Editor to this article was published on 13 February 2014

Abstract

Purpose

Significant malnutrition exists in a high percentage of patients with gastric cancer. It is, therefore, crucial to establish an effective means to provide nutrition for these patients. This prospective, randomized, double-blinded clinical trial aims to assess the long-term survival of arginine-supplementation enteral nutrition versus standard enteral nutrition in malnourished patients with gastric cancer.

Methods

The control group (36 cases) received postoperative standard enteral nutrition. Meanwhile, the arginine-supplementation group (37 cases) adopted the same nutrition product but enriched with arginine (9.0 g/L). The primary study objective was overall survival (OS). Secondary endpoints were progression-free survival (PFS); serum parameters including total protein, albumin, proalbumin, and transferrin obtained on preoperative day 1, postoperative day 2, and day 12; CD4+ and CD8+ T cells, natural killer (NK) cells, immunoglobulin M (IgM), and immunoglobulin G (IgG) obtained on preoperative day 1 and postoperative day 7.

Results

No significant differences in baseline characteristics were observed between groups. The group receiving arginine-enriched nutrition had a significantly better OS (P = 0.03, 41 vs. 30.5 months) and better PFS (P = 0.02, 18 vs. 11.5 months). On postoperative day 7, CD4+ T cells, NK cells, IgM and IgG levels of the arginine-supplemented group increased prominently and were significantly higher than those of the control group and those on preoperative day 1. There is no significant difference in the serum total protein, albumin, proalbumin, and transferrin levels between the two arms.

Conclusions

Arginine-supplemented enteral nutrition significantly improves long-term survival and restores immunity in malnourished gastric cancer.

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Conflict of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Department of Intensive Care Unit, Daqing Oilfield General Hospital, Daqing, 163001, China

    Hongyan Zhao

  2. Department of Oncology, Daqing Longnan Hospital, Daqing, 163453, China

    Hongying Zhao

  3. Department of General Surgery, Daqing Longnan Hospital, Daqing, 163453, China

    Yu Wang

  4. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Huang Jing, Qian Ding & Jun Xue

Authors
  1. Hongyan Zhao
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  2. Hongying Zhao
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  3. Yu Wang
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  4. Huang Jing
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  5. Qian Ding
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  6. Jun Xue
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Corresponding author

Correspondence to Jun Xue.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00432-015-1913-6.

Our paper entitled “Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery” reported that arginine-supplemented enteral nutrition significantly improved long-term survival and restored immunity in malnourished gastric cancer. However, recently we checked our data again and found there was an obvious difference between experimental and control groups in the tumor status at the beginning of the trial. In addition, the sample size was not calculated, which might be not enough to reach a significant power. Thus, the trial might be biased and we, the authors, believe that the most responsible course of action is to retract our paper. We deeply regret this circumstance and apologize to the community.

A comment to this article is available at http://dx.doi.org/10.1007/s00432-014-1608-4.

A comment to this article is available at http://dx.doi.org/10.1007/s00432-014-1609-3.

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Zhao, H., Zhao, H., Wang, Y. et al. RETRACTED ARTICLE: Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery. J Cancer Res Clin Oncol 139, 1465–1470 (2013). https://doi.org/10.1007/s00432-013-1466-5

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  • DOI: https://doi.org/10.1007/s00432-013-1466-5

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