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Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review

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Abstract

We report a 2-year-old Japanese boy without bone marrow involvement who developed a primary granulocytic sarcoma in his spinal canal. Tumour cells were positive for myeloperoxidase, MIC2, CD56 and, CD68 on formalin-fixed, paraffin-embedded tissue sections and CD13, CD33, CD45, and CD64 on acetone-fixed fresh frozen sections. Nine months after the initiation of treatment, the tumour had significantly regressed and the patient was able to walk with help. Conclusion:Our patient is the youngest case of granulocytic sarcoma of the spine without bone marrow involvement. Immunohistochemical methods are very helpful in establishing a diagnosis of granulocytic sarcoma.

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Abbreviations

AML :

acute myeloid leukaemia

GS :

granulocytic sarcoma

References

  1. Brunning RD, Matutes E, Flandrin G, Vardiman J, Bennett J, Head D, Harris NL (2001) Acute myeloid leukemia not otherwise categorised. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) Pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 104–105

  2. Buckland ME, Scolyer RA, Donellan MB, Brew S, McGee-Collett M, Harper CG (2001) Spinal chloroma presenting with triplegia in an aleukaemic patient. Pathology 33: 386–389

    CAS  PubMed  Google Scholar 

  3. Chan JKC, Lau WH, Saw D (1986) Extradural granulocytic sarcoma of the spine: a unique case of long survival after local therapy. Am J Hematol 22: 439–441

    CAS  PubMed  Google Scholar 

  4. Chen J, Yanuck RR, Abbondanzo SL, Chu W-S, Aguilera NSI (2001) C-Kit (CD117) reactivity in extramedullary myeloid tumor/granulocytic sarcoma. Arch Pathol Lab Med 125: 1448–1452

    CAS  PubMed  Google Scholar 

  5. Deme S, Deodhare SS, Tucker WS, Bilbao JM (1997) Granulocytic sarcoma of spine in nonleukemic patients: report of three cases. Neurosurgery 40: 1283–1287

    CAS  PubMed  Google Scholar 

  6. Eshghabadi M, Shajania AM, Carr I (1986) Isolated granulocytic sarcoma: report of a case and review of the literature. J Clin Oncol 4: 912–917

    CAS  PubMed  Google Scholar 

  7. Graham A, Hodgson T, Jacubowski J, Norfolk D, Smith C (2001) MRI of perineural extramedullary granulocytic sarcoma. Neuroradiology 43: 492–495

    CAS  PubMed  Google Scholar 

  8. Kim FSC, Rutka JT, Bernstein M, Resch L, Warner E, Pantalony D (1990) Intradural granulocytic sarcoma presenting as a lumbar radiculopathy. J Neurosurg 72: 663–667

    CAS  PubMed  Google Scholar 

  9. Lagrange M, Gaspard M-H, Lagrange J-L, Michiels J-F, Hofman P, Thyss A, Schneider M (1992) Granulocytic sarcoma with meningeal leukemia but no bone marrow involvement at presentation. A report of two cases with characteristic cerebrospinal fluid cytology. Acta Cytol 36: 319–324

    CAS  PubMed  Google Scholar 

  10. MaCarty KS Jr, Wortman J, Daly J, Rundles W, Hanker JS (1980) Chloroma (granulocytic sarcoma) without evidence of leukemia: facilitated light microscopic diagnosis. Blood 56: 104–108

    PubMed  Google Scholar 

  11. Machii R, Muto A, Okano Y, Akizuki M, Katsumata Y (2000) Granulocytic sarcoma presenting as an epidural mass with spinal cord compression. Jpn J Clin Hematol 41: 653–657

    CAS  Google Scholar 

  12. Manson TE, Demaree RS Jr, Margolis CI (1973) Granulocytic sarcoma (chloroma), two years preceding myelogenous leukemia. Cancer 31: 423–432

    PubMed  Google Scholar 

  13. Meis JM, Butler JJ, Osborne BM, Manning JT (1986) Granulocytic sarcoma in nonleukemic patients. Cancer 58: 2697–2709

    CAS  PubMed  Google Scholar 

  14. Menasce LP, Banerjee SS, Beckett E, Harris M (1999) Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagdosed: a study of 26 cases. Histopathology 34: 391–398

    CAS  PubMed  Google Scholar 

  15. Mostafavi H, Lennarson PJ, Traynelis VC (2000) Granulocytic sarcoma of the spine. Neurosurgery 46: 78–84

    CAS  PubMed  Google Scholar 

  16. Neiman RS, Barcos M, Berard C, Bonner H, Mann R, Rydell RE, Bennett JM (1981) Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer 48: 1426–1437

    CAS  PubMed  Google Scholar 

  17. Ragins AB, Tinsley M (1950) Chloroma: report of a case. J Neuropathol Exp Neurol 9: 186–192

    CAS  PubMed  Google Scholar 

  18. Ripp DJ, Davis JW, Rengachary SS, Lotuaco LG, Watanabe IS (1989) Granulocytic sarcoma presenting as an epidural mass with cord compression. Neurosurgery 24: 125–128

    CAS  PubMed  Google Scholar 

  19. Sajjad Z, Haq N, Kandula V (1997) Case report: granulocytic sarcoma (GS) presenting as acute cord compression in a previously undiagnosed patient. Clin Radiol 52: 69–71

    CAS  PubMed  Google Scholar 

  20. Sandhu GS, Ghufoor K, Gonzalez-Garcia J, Elexpuru-Camiruaga JA (1998) Granulocytic sarcoma presenting as cauda equina syndrome. Clin Neurol Neurosurg 100: 205–208

    CAS  PubMed  Google Scholar 

  21. Tsimberidou A-M, Kantarjian HM, Estey E, Cortes JE, Verstovsek S, Faderl S, Thomas DA, Garcia-Manero G, Ferrajoli A, Manning JT, Keating MJ, Albitar M, O’Brien S, Giles FJ (2003) Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy. Leukemia 17: 1100–1103

    PubMed  Google Scholar 

  22. Ugras S, Cirak B, Karakok M, Guven B (2001) Spinal epidural granulocytic sarcoma (chloroma) in a non-leukemic child. Pediatr Int 43: 505–507

    CAS  PubMed  Google Scholar 

  23. Watanabe M, Sashikata T, Kizaki T, Fujiwara T, Ugai K, Nakagawa T (1990) A case of epidural granulocytic sarcoma preceding acute leukemia. Acta Pathol Jpn 40: 922–926

    CAS  PubMed  Google Scholar 

  24. Wilhyde DE, Jane JA, Mullan S (1963) Spinal epidural leukemia. Am J Med 34: 281–287

    CAS  PubMed  Google Scholar 

  25. Williams M, Olliff JFC, Rowley MR (1990) CT and MR findings in parameningeal leukaemic masses. J Comput Assist Tomogr 14: 736–742

    CAS  PubMed  Google Scholar 

  26. Yamauchi K, Yasuda M (2002) Comparison in treatments of nonleukemic granulocytic sarcoma. Cancer 94: 1739–1746

    PubMed  Google Scholar 

  27. Zhang PJ, Barcos M, Stewart CC, Block AW, Sait S, Brools JJ (2000) Immunoreactivity of MIC2 (CD99) in acute myelogenous leukemia and related diseases. Mod Pathol 13: 452–458

    CAS  PubMed  Google Scholar 

  28. Zuiable A, Aboud H, Nandi A, Powles R, Treleaven J (1989) Extramedullary disease initially without bone marrow involvememt in acute promyelocytic leukemia (letter). Clin Lab Haematol 2: 288–289

    Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan

    Yusuke Shiozawa, Masahiro Saito & Yuichiro Yamashiro

  2. Department of Developmental Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, 154-8535, Tokyo , Japan

    Yusuke Shiozawa, Nobutaka Kiyokawa, Junichiro Fujimoto & Jun-ichi Hata

Authors
  1. Yusuke Shiozawa
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  2. Nobutaka Kiyokawa
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  3. Masahiro Saito
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  4. Junichiro Fujimoto
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  5. Jun-ichi Hata
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  6. Yuichiro Yamashiro
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Correspondence to Yusuke Shiozawa.

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Shiozawa, Y., Kiyokawa, N., Saito, M. et al. Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review. Eur J Pediatr 164, 616–620 (2005). https://doi.org/10.1007/s00431-005-1728-6

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  • DOI: https://doi.org/10.1007/s00431-005-1728-6

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