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A large-scale clinicopathological and long-term follow-up study of solid papillary carcinoma of the breast

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Abstract

Solid papillary carcinoma of the breast (SPC) is a rare tumor of the breast with the unique histology and frequent neuroendocrine differentiation. However, a real nature and diagnostic importance of the neuroendocrine differentiation have not been properly handled. And relationship between SPC and the other types of invasive breast carcinoma, especially neuroendocrine tumor of the breast (NETb), has not been fully explained. We conducted a clinicopathological study of SPC to tackle these problems.

In the study, we included 127 cases of SPC with long-term follow-ups of up to 30 years. The incidence in the breast carcinoma was 2.0%. The patients with SPC had a significantly better prognosis and no patients died of the tumor. The 35 cases had only SPC in situ (SPC-IS), while the 92 cases had both SPC-IS and SPC with invasion (SPC-INV). Immunohistochemically, 123 of the 127 cases exhibited diffuse expression of one or more neuroendocrine markers. Fifty of the 92 cases had exclusively invasive SPC (iSPC) as the invasive component. Twenty-two cases of iSPC were combined with NETb and the 18 cases with MUC. Six of 8 cases with metastatic SPC-INV disclosed iSPC in the axillary lymph node.

This study suggests that SPC is immunohistochemically compatible with NET of the systemic organs (NETs). And the unique morphology of SPC may represent a traditional histology of NETs. The study also indicates that SPC has close relationship between NETb and type B MUC. And SPC and NETb may represent a spectrum of the same disease.

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Data Availability

The data that support the findings of this study are available from the corresponding author, upon reasonable request.

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Acknowledgements

The authors thank all the staff of the clinical technologists at the Department of Clinical Laboratory, Seirei Hamamatsu General Hospital, Hamamatsu, Japan, for their excellent technical assistance.

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Authors and Affiliations

  1. Department of Pathology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

    Yoshiro Otsuki, Shunsuke Ohtsuka, Shin-ichi Shimizu & Hiroshi Kobayashi

  2. Department of Surgery, Seirei Mikatahara General Hospital, Hamamatsu, Japan

    Kaori Suwa

  3. Department of Breast Surgery, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

    Natsuko Mori & Masayuki Yoshida

  4. Department of Surgery, Seirei Numazu Hospital, Numazu, Japan

    Atsushi Serizawa

  5. Department of Pathology, Tachikawa General Hospital, Nagaoka, Japan

    Hiroshi Kobayashi

Authors
  1. Yoshiro Otsuki
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  2. Kaori Suwa
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  3. Shunsuke Ohtsuka
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  4. Natsuko Mori
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  5. Masayuki Yoshida
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  6. Atsushi Serizawa
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  7. Shin-ichi Shimizu
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  8. Hiroshi Kobayashi
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Contributions

Yoshiro Otsuki and Hiroshi Kobayashi designed and drafted the manuscript. Yoshiro Otsuki, Shunsuke Ohtsuka, Shin-ichi Shimizu, and Hiroshi Kobayashi made the histopathological diagnoses. Kaori Suwa, Natsuko Mori, Masayuki Yoshida, and Atsushi Serizawa collected the clinical data. All of the authors have read and approved the final manuscript.

Corresponding author

Correspondence to Yoshiro Otsuki.

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This study has been approved by the institutional review board of Seirei Hamamatsu General Hospital.

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The authors declare no competing interests.

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Otsuki, Y., Suwa, K., Ohtsuka, S. et al. A large-scale clinicopathological and long-term follow-up study of solid papillary carcinoma of the breast. Virchows Arch 482, 687–695 (2023). https://doi.org/10.1007/s00428-023-03489-7

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  • DOI: https://doi.org/10.1007/s00428-023-03489-7

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