Abstract
We present a further case of a rare mesenchymal neoplasm termed phosphaturic mesenchymal tumor (mixed connective tissue variant). The patient was a 42-year-old man with a long history of osteomalacia of unknown etiology with pathological bone fracture, abnormality of parathyroid glands, kyphosis, scoliosis, and spondylosis. Laboratory investigation disclosed hypophosphatemia, elevated serum alkaline phosphatase activity, and normal serum calcium level. The patient had a soft tissue mass in the right inguinal area, measuring 11×6×5 cm, which was previously interpreted as a calcified hematoma on sonography. The tumor was surgically removed. Grossly, the tumor was well circumscribed, unencapsulated, and had soft to dense consistency. The cut surface had a variegated appearance due to the presence of large hemorrhagic areas admixed with foci of grey-yellow tissue. Histologically, the tumor was composed of primitive mesenchymal cells, osteoclast-like cells, and cells showing myofibroblastic features without cytologic atypia. There were a well developed vascular network, microcystic areas, and poorly formed cartilaginous foci. Unusual and hitherto unpublished prominent features were flower-like, slate-gray crystals, widespread hemosiderin deposits and large areas of hemorrhages, with the latter comprising approximately 60% of the tumor. A spectral analysis indicated that chemically, the crystals mainly consisted of calcium phosphate and sodium nitrate.
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Cehreli CA, Alakavuklar MN, Cavdar C (1994) Oncogenous osteomalacia: report of a case. Acta Oncol 33:975–976
Firth RG, Grant CS, Riggs BL (1985) Development of hypercalcemic hyperparathyroidism after long-term phosphate supplementation in hypophosphatemic osteomalacia: report of two cases. Am J Med 78:669–673
Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY, Econs MJ, Inwards CY, Jan de Beur SM, Mentzel T, Montgomery E, Michal M, Miettinen M, Mills SE, Reith JD, O’Connell JX, Rosenberg AE, Rubin BP, Sweet DE, Vinh TN, Wold LE, Wehrli BM, White KE, Zaino RJ, Weiss SW (2004) Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 28:1–30
McClure J, Smith PS (1987) Oncogenic osteomalacia. J Clin Pathol 40:446–453
Papotti M, Foschini MP, Isaia G, Rizzi G, Betts CM, Eusebi V (1988) Hypophosphatemic oncogenic osteomalacia: report of three new cases. Tumori 74:599–607
Reid IR, Teitelbaum SL, Dusso A, Whyte MP (1987) Hypercalcemic hyperparathyroidism complicating oncogenic osteomalacia: effect of successful tumor resection on mineral homeostasis. Am J Med 83:350–354
Weidner N, Santa Cruz D (1987) Phosphaturic mesenchymal tumors: a polymorphous group causing osteomalacia or rickets. Cancer 59:1442–1454
Weidner N (1991) Review and update: oncogenic osteomalacia-rickets. Ultrastruct Pathol 15:317–333
Yang IM, Park YK, Hyun YJ (1997) Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the oral cavity: a case report. Korean J Intern Med 12:89–95
Acknowledgement
The authors wish to thank Dr. Marek Chvátal from the Institute of Geochemistry, Mineralogy and Mineral Resources, Faculty of Science, Charles University, Prague, Czech Republic, who performed the spectral analysis.
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Shelekhova, K.V., Kazakov, D.V., Hes, O. et al. Phosphaturic mesenchymal tumor (mixed connective tissue variant): a case report with spectral analysis. Virchows Arch 448, 232–235 (2006). https://doi.org/10.1007/s00428-005-0149-2
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DOI: https://doi.org/10.1007/s00428-005-0149-2