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Multifaceted roles of STIM proteins

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Abstract

Stromal interaction molecules (STIM1 and STIM2) are critical components of store-operated calcium entry. Sensing depletion of endoplasmic reticulum (ER) Ca2+ stores, STIM couples with plasma membrane Orai channels, resulting in the influx of Ca2+ across the PM into the cytosol. Although best recognized for their primary role as ER Ca2+ sensors, increasing evidence suggests that STIM proteins have a broader variety of sensory capabilities than first envisaged, reacting to cell stressors such as oxidative stress, temperature, and hypoxia. Further, the array of partners for STIM proteins is now understood to range far beyond the Orai channel family. Here we discuss the implications of STIM’s expanding role, both as a stress sensor and a general modulator of multiple physiological processes in the cell.

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Acknowledgments

This work was funded by NIH grant #GM097335 (JS).

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  1. Department of Biochemistry, Temple University School of Medicine, 3440 North Broad Street, Philadelphia, PA, 19140, USA

    Robert Hooper, Elsie Samakai, Joseph Kedra & Jonathan Soboloff

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  1. Robert Hooper
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  2. Elsie Samakai
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  3. Joseph Kedra
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  4. Jonathan Soboloff
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Correspondence to Jonathan Soboloff.

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Hooper, R., Samakai, E., Kedra, J. et al. Multifaceted roles of STIM proteins. Pflugers Arch - Eur J Physiol 465, 1383–1396 (2013). https://doi.org/10.1007/s00424-013-1270-8

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  • DOI: https://doi.org/10.1007/s00424-013-1270-8

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