Abstract
Since their identification in the concluding years of the last century, the mammalian transient receptor potential (canonical) (TRPC) channels have remained in the limelight as the primary candidates for the Ca2+ entry pathway activated by the hormones, growth factors, and neurotransmitters that exert their effect through activation of PLC. Although TRPC channels have been shown clearly to mediate, at least in part, receptor-activated Ca2+ entry in literally all cell types, several of their central characteristics, as recorded in expression systems using recombinant channels, differ from those of the native receptor-dependent Ca2+ influx channels. The present review attempts to highlight the interaction of TRPC channels with other proteins, which may explain the variability of TRPC channel activation and regulatory mechanisms observed with the native and recombinant channels. These include the homologous and heterotopous interactions of TRPC channel isoforms, the interaction of TRPC channels with calmodulin, PLCγ, IP3 receptors, and with scaffolding proteins like InaD, EBP50/NEHRF, caveolin, Janctate and Homers.
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Abbreviations
- αSNAP:
-
α-Soluble N-ethylmaleimide-sensitive factor attachment protein
- CaM:
-
Calmodulin
- CaMKII:
-
Calmodulin kinase II
- EBP50:
-
Ezrin-radixin-moesin-binding protein, 50 kD
- EGF:
-
Epidermal growth factor
- ER:
-
Endoplasmic reticulum
- FKBP:
-
FK506 binding protein
- FL:
-
Full length
- GPCR:
-
G protein-coupled receptor
- InaD:
-
Inactivation no after-potential D
- IP3:
-
Inositol trisphosphate
- IP3R:
-
IP3 receptor
- LTP:
-
Long-term potentiation
- mGluR5:
-
Metabotropic glutamate receptor type 5
- NHERF:
-
Na+/H+ exchanger regulatory factor
- NorpA:
-
No receptor potential A
- OAG:
-
1-oleoyl-2-acetyl-sn-glycerol
- PDZ domain:
-
Postsynaptic density/discs-large/zonula occludens domain
- PH domain:
-
Plekstrin homology domain
- PI3K:
-
Phosphatidylinositol-3-kinase
- PIP2:
-
Phosphatidyl inositol bisphosphate
- PKC:
-
Protein kinase C
- PLC:
-
Phospholipase C
- PM:
-
Plasma membrane
- RGS:
-
Regulator of G protein signaling
- SH domain:
-
Src homology domain
- SNARE:
-
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor
- SPL:
-
Spinophilin
- TRPC:
-
Mammalian transient receptor potential (canonical) channel
- VAMP:
-
Vesicle-associated membrane protein
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Kiselyov, K., Kim, J.Y., Zeng, W. et al. Protein-protein interaction and functionTRPC channels. Pflugers Arch - Eur J Physiol 451, 116–124 (2005). https://doi.org/10.1007/s00424-005-1442-2
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DOI: https://doi.org/10.1007/s00424-005-1442-2