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Silicone prosthetics and anti-thyroid autoimmunity

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Abstract

Introduction

In esthetic surgery, the use of silicone implants is a topic of hot discussion.

Material and methods

An analysis of 119 esthetic surgical interventions on the mammary gland was performed. A study of the immune and endocrine parameters after mammoplasty was carried out.

Results

The phenomenon of an increase in the levels of autoantibodies to the TSH receptor was revealed. The phenomenon of pre-operative growth of prolactin and TSH levels has been confirmed. An increase in thyroid autoimmunity after silicone mammoplasty is interpreted as a result of a silicone adjuvant action. An increase in the incidence of ASIA syndrome in patients who underwent breast surgery was registered. However, it was observed in both patients with silicone and non-silicone breast surgeries and therefore could not be solely explained by the use of silicone. Within 12 months following silicone mammoplasty, the patients with an increase of anti-TSH receptor autoimmunity nevertheless did not show any clinical and laboratory signs of overt thyroid disease, thus staying in a pre-nosological state.

Practical recommendations

Based on these results, we recommend the following for esthetic surgery: (a) all patients planned for silicone implant surgery should be examined for autoantibodies to the TSH receptor and (b) patients who have undergone breast endoprosthesis, starting 6 months after the operation, need long-term follow-up for thyroid status with mandatory testing for the level of these autoantibodies.

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Funding

This study was funded by the grant of the Government of the Russian Federation#14.W03.31.0009, agreement of 13 .02.2017.

Author information

Authors and Affiliations

  1. St. Petersburg State Budgetary Healthcare Institution “City Hospital No. 40 of the Kurortny district”, 9, Borisova ul., St. Petersburg, Russian Federation, 197706

    V. G. Zolotykh

  2. St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, Russian Federation, 199034

    V. G. Zolotykh, V. J. Utekhin, L. P. Churilov, Y. Shoenfeld & P. K. Yablonskiy

  3. North-Western State Medical University named after I.I. Mechnikov, 41, Kirochnaya ul., St. Petersburg, Russian Federation, 191015

    A. N. Gvozdetckii

  4. Saint Petersburg State University of Economics – UNECON, 30-32, Griboedov canal nab., St. Petersburg, Russian Federation, 191023

    V. A. Maevskaya

  5. Saint Petersburg State Pediatric Medical University, 2, Litovskaya ul, St. Petersburg, Russian Federation, 194100

    V. J. Utekhin

  6. St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, Russian Federation, 191036

    L. P. Churilov & P. K. Yablonskiy

  7. Ariel University, 65, Ramat HaGolan St., 4077625, Ariel, Israel

    Y. Shoenfeld

Authors
  1. V. G. Zolotykh
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  2. A. N. Gvozdetckii
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  3. V. A. Maevskaya
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  4. V. J. Utekhin
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  5. L. P. Churilov
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  6. Y. Shoenfeld
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  7. P. K. Yablonskiy
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Contributions

Study conception and design: V. G. Zolotykh, A. N. Gvozdetckii, L. P. Churilov, P. K. Yablonsky, Y. Shoenfeld; acquisition of data, surgery: V. G. Zolotykh; analysis and interpretation of data: A. N. Gvozdetckii, V. G. Zolotykh, L. P. Churilov, V. J. Utekhin, P. K. Yablonsky; drafting of manuscript: V. G. Zolotykh, V. A. Mayevskaya, V. J. Utekhin; critical revision of manuscript: V. G. Zolotykh, L. P. Churilov, P. K. Yablonsky, Y. Shoenfeld.

Corresponding author

Correspondence to V. G. Zolotykh.

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Zolotykh, V.G., Gvozdetckii, A.N., Maevskaya, V.A. et al. Silicone prosthetics and anti-thyroid autoimmunity. Langenbecks Arch Surg 408, 312 (2023). https://doi.org/10.1007/s00423-023-03030-z

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