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Pathology of intraductal papillary mucinous neoplasms

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Abstract

Background

Intraductal papillary mucinous neoplasms (IPMNs) represent a unique opportunity to treat and prevent a curable neoplasm before it has the chance to progress to incurable cancer. This prospect, however, has to be balanced with the real risk of over treating patients with lesions that would, in fact, never progress during the life of the patient.

Purpose

Informed clinical decisions in the treatment of IPMNs are first and foremost based on a deep understanding of the pathology of these lesions.

Conclusions

Here we review the pathology of IPMNs, with an emphasis on the clinical relevance of the important features that characterize these lesions.

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Authors and Affiliations

  1. Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21212, USA

    Naziheh Assarzadegan, Elizabeth Thompson, Kevan Salimian, Laura Wood, Syed Z. Ali & Ralph H. Hruban

  2. Institute of Pathology, University Medical Center Mainz, Mainz, Germany

    Matthias M. Gaida

  3. Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

    Lodewijk A.A. Brosens

  4. Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21212, USA

    Laura Wood, Syed Z. Ali & Ralph H. Hruban

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  1. Naziheh Assarzadegan
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  2. Elizabeth Thompson
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Correspondence to Ralph H. Hruban.

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Under a license agreement between, Thrive Earlier Detection Corp., a subsidiary of Exact Sciences Corp., and the Johns Hopkins University, Dr. Hruban and the University are entitled to royalty distributions related to the GNAS invention described in this review. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest’s policies.

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Assarzadegan, N., Thompson, E., Salimian, K. et al. Pathology of intraductal papillary mucinous neoplasms. Langenbecks Arch Surg 406, 2643–2655 (2021). https://doi.org/10.1007/s00423-021-02201-0

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