Abstract
The effect of graded ischaemia in the legs on the regulation of body temperature during steady-state exercise was investigated in seven healthy males. It was hypothesised that graded ischaemia in the working muscles increases heat storage within the muscles, which in turn potentiates sweat secretion during exercise. Blood perfusion in the working muscles was reduced by applying a supra-atmospheric pressure (+6.6 kPa) around the legs, which reduced maximal working capacity by 29%. Each subject conducted three separate test trials comprising 30 min of steady-state cycling in a supine position. Exercise with unrestricted blood flow (Control trial) was compared to ischaemic exercise conducted at an identical relative work rate (Relative trial), as well as at an identical absolute work rate (Absolute trial); the latter corresponding to a 20% increase in relative workload. The average (SD) increases in both the rectal and oesophageal temperatures during steady-state cycling was 0.3 (0.2)°C and did not significantly differ between the three trials. The increase in muscle temperature was similar in the Control (2.7 (0.3)°C) and Absolute (2.4 (0.7)°C) trials, but was substantially lower (P<0.01) in the Relative trial (1.4 (0.8)°C). Ischaemia potentiated (P<0.01) sweating on the forehead in the Absolute trial (24.2 (7.3) g m−2 min−1) compared to the Control trial (13.4 (6.2) g m−2 min−1), concomitant with an attenuated (P<0.05) vasodilatation in the skin during exercise. It is concluded that graded ischaemia in working muscles potentiates the exercise sweating response and attenuates vasodilatation in the skin initiated by increased core temperature, effects which may be attributed to an augmented muscle metaboreflex.
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References
Bini G, Hagbarth KE, Hynninen P, Wallin BG (1980) Regional similarities and differences in thermoregulatory vaso- and sudomotor tone. J Physiol 306:553–565
Bjurstedt H, Eiken O (1995) Graded restriction of blood flow in exercising leg muscles: a human model. Adv Exp Med Biol 381:147–156
Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14:377–381
Davies CT, Brotherhood JR, Zeidifard E (1976) Temperature regulation during severe exercise with some observations on effects of skin wetting. J Appl Physiol 41:772–776
Eiken O (1987) Responses to dynamic leg exercise in man as influenced by changes in muscle perfusion pressure. Acta Physiol Scand Suppl 566:1–37
Eiken O, Bjurstedt H (1987) Dynamic exercise in man as influenced by experimental restriction of blood flow in the working muscles. Acta Physiol Scand 131:339–345
Eiken O, Mekjavic IB (2004) Ischaemia in working muscles potentiates the exercise-induced sweating response in man. Acta Physiol Scand 181:305–311
Fox RH, Hilton SM (1958) Bradykinin formation in human skin as a factor in heat vasodilatation. J Physiol 142:219–232
Fox RH, Goldsmith R, Kidd DJ, Lewis GP (1961) Bradykinin as a vasodilator in man. J Physiol 157:589–602
Frewin DB, McConnell DJ, Downey JA (1973) Is a kininogenase necessary for human sweating. Lancet 2:744
House JR, Tipton MJ (2002) Using skin temperature gradients or skin heat flux measurements to determine thresholds of vasoconstriction and vasodilatation. Eur J Appl Physiol 88:141–145
Johnson JM (1986) Nonthermoregulatory control of human skin blood flow. J Appl Physiol 61:1613–1622
Kellogg DL, Johnson JM, Kosiba WA (1991) Control of internal temperature threshold for active cutaneous vasodilation by dynamic exercise. J Appl Physiol 71:2476–2482
Kellogg DL, Liu Y, McAllister K, Friel C, Pergola PE (2002) Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans. J Appl Physiol 93:1215–1221
Kondo N, Tominaga H, Shibasaki M, Aoki K, Koga S, Nishiyasu T (1999) Modulation of the thermoregulatory sweating response to mild hyperthermia during activation of the muscle metaboreflex in humans. J Physiol 515(Pt 2):591–598
Mack G, Nishiyasu T, Shi X (1995) Baroreceptor modulation of cutaneous vasodilator and sudomotor responses to thermal stress in humans. J Physiol 483(Pt 2):537–547
Mekjavic IB, Rempel ME (1990) Determination of esophageal probe insertion length based on standing and sitting height. J Appl Physiol 69:376–379
Mense S (1978) Effects of temperature on the discharges of muscle spindles and tendon organs. Pflugers Arch 374:159–166
Nielsen B (1969) Thermoregulation in rest and exercise. Acta Physiol Scand Suppl 323:1–74
Robinson S, Meyer FR, Newton JL, Ts’Ao CH, Holgersen LO (1965) Relations between sweating, cutaneous blood flow, and body temperature in work. J Appl Physiol 20:575–582
Rotto DM, Schultz HD, Longhurst JC, Kaufman MP (1990) Sensitization of group III muscle afferents to static contraction by arachidonic acid. J Appl Physiol 68:861–867
Rowell LB (1977) Reflex control of the cutaneous vasculature. J Invest Dermatol 69:154–166
Rowell LB (1983) Cardiovascular adjustments to thermal stress. In: Sheperd JT, Abboud FM, Geiger SR (eds) Handbook of physiology. The cardiovascular system: peripheral circulation and organ blood flow, Section 2, vol III. American Physiological Society, Methesda, MD, pp 967–1023
Rubinstein EH and Sessler DI (1990) Skin-surface temperature gradients correlate with fingertip blood flow in humans. Anesthesiology 73:541–545
Saltin B (1970) Circulation adjustments and body temperature regulation during exercise. In: Hardy JD, Gagge AP, Stolwijk JAJ (eds) Physiological and behavioural temperature regulation. Charles C Thomas, Springfield, pp 316–323
Saltin B, Hermansen L (1966) Esophageal, rectal, and muscle temperature during exercise. J Appl Physiol 21:1757–1762
Saltin B, Gagge AP, Stolwijk JA (1968) Muscle temperature during submaximal exercise in man. J Appl Physiol 25:679–688
Saltin B, Gagge AP, Stolwijk JA (1970) Body temperatures and sweating during thermal transients caused by exercise. J Appl Physiol 28:318–327
Sessler DI, Olofsson CI, Rubinstein EH, Beebe JJ (1988) The thermoregulatory threshold in humans during halothane anesthesia. Anesthesiology 68:836–842
Shibasaki M, Kondo N, Crandall CG (2001) Evidence for metaboreceptor stimulation of sweating in normothermic and heat-stressed humans. J Physiol 534:605–611
Sundberg CJ and Kaijser L (1992) Effects of graded restriction of perfusion on circulation and metabolism in the working leg; quantification of a human ischaemia-model. Acta Physiol Scand 146:1–9
Sundberg CJ, Eiken O, Nygren A, Kaijser L (1993) Effects of ischaemic training on local aerobic muscle performance in man. Acta Physiol Scand 148:13–19
Van Beaumont W, Bullard RW (1966) Sweating exercise stimulation during circulatory arrest. Science 152:1521–1523
Wallin BG, Sundlof G, Delius W (1975) The effect of carotid sinus nerve stimulation on muscle and skin nerve sympathetic activity in man. Pflugers Arch 358:101–110
Wilson TE, Cui J, Crandall CG (2001) Absence of arterial baroreflex modulation of skin sympathetic activity and sweat rate during whole-body heating in humans. J Physiol 536:615–623
Acknowledgements
This study was supported by a grant from the Ministry of Education, Science and Sport of the Republic of Slovenia to Igor B. Mekjavic. Alan Kacin is a recipient of a Young Investigator Postgraduate Scholarship from the same institution. The authors are also indebted to TIK d.o.o., Kobarid, Slovenia, for technical support in the development of muscle temperature sensors.
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Kacin, A., Golja, P., Eiken, O. et al. Human temperature regulation during cycling with moderate leg ischaemia. Eur J Appl Physiol 95, 213–220 (2005). https://doi.org/10.1007/s00421-005-1387-3
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DOI: https://doi.org/10.1007/s00421-005-1387-3