Abstract
Objective
Considering household disinfectants and cleaning products (HDCP) as mixture of ingredients, rather than each ingredient individually, might help in characterizing their role in asthma. We investigated the association between HDCP and asthma, using the recently developed Ménag’Score®, a health risk assessment score based on exhaustive ingredient lists of HDCP.
Methods
The study is based on 103 female volunteers of the SEPAGES cohort (2014–2019), with repeated data (up to 3 collection times, 200 observations). HDCP use was assessed from a barcode-based smartphone application linked with an ingredient database. The Ménag’score® risks for health and environment were computed for each weekly used HDCP from their exhaustive ingredient data (from A: no known risk to E: highest risk). The association between the use of HDCP with a poor Ménag’score® (D or E; overall, health, environment scores) and asthma symptoms, was estimated by generalized estimating equations models adjusted for age, BMI and smoking status.
Results
Participants were on average 33 years old, 11% smoked and 20% had at least one asthma symptom. The Ménag’score® was computed for 540 HDCP scanned by participants. Weekly use of HDCP with a poor Ménag'score®-health (around 60% of the participants) was associated with a higher risk of asthma symptoms (OR 3.13, 95% CI [1.32–7.43]). No association was observed for the Ménag'score®-environment.
Conclusion
The use of HDCP with a poor Ménag’score®-health was associated with asthma symptoms. The results support the use of the Ménag’score®-health to further evaluate the health risks of HDCP in observational studies and as a potential public health tool.
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Data availability
The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request and with the permission of the SEPAGES Study group.
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Acknowledgements
We thank Mrs. A. Benlakhryfa, Mrs. L. Borges, Mr. Y. Gioria, clinical research assistants; Mrs. J. Giraud, Mrs. M. Marceau, Mrs. M-P. Martin, nurses; Mrs. E. Charvet, Mrs A. Putod, midwives; Mrs. M. Graca, Mrs. K.Gridel, Mrs. C. Pelini, Mrs Maïlys Barbagallo fieldworkers; Mrs. A.Bossant, K. Guichardet, J-T Iltis A. Levanic, C.Martel, E. Quinteiro, S.Raffin neuropsychologists; the staff from Grenoble Center for Clinical Investigation (CIC): Prof. J.-L. Cracowski, Dr. C. Cracowski,Dr. E. Hodaj, Mrs. D. Abry, Mr. N. Gonnet and Mrs. A. Tournier. A warm thank you also to Dr. M. Althuser, Mr. S. Althuser, Dr. F. Camus-Chauvet, Mr. P. Dusonchet, Mrs. S. Dusonchet, Dr. L. Emery, Mrs. P.Fabbrizio, Prof. P. Hoffmann, Dr. D. Marchal André, Dr. X. Morin, Dr. E.Opoix, Dr. L. Pacteau, Dr. P. Rivoire, Mrs. A. Royannais, Dr. C.Tomasella, Dr. T. Tomasella, Dr. D. Tournadre, Mr. P. Viossat, Mrs. E.Volpi, Mrs. S. Rey, Dr. E. Warembourg and clinicians from Grenoble University Hospital for their support in the recruitment of the study volunteers. We also thank Mrs. A. Buchet, Mrs. SF. Caraby, Dr. J-N.Canonica, Mrs. J. Dujourdil, Dr. E. Eyriey, Prof. P. Hoffmann, Mrs. M.Jeannin, Mrs. A. Licina, Dr. X. Morin, Mrs. A. Nicolas, and all midwives from the four maternity wards of Grenoble urban areas. SEPAGES data are stored thanks to Inserm RE-CO-NAI platform funded by Commissariat Général à l’Investissement, with the implication of Sophie de Visme (Inserm DSI). Many thanks to Dr. M.A. Charles, RE-CO-NAI coordinator, for her support. The authors are grateful for the help received from Ines Taarit, Mathias Clément and Sophie Remacle to update the cleaning products ingredients database, Baptiste Vierne from INC for the help with the Ménag’score® and Karine Supernant and Anne Boudier for their help in the data management of SEPAGES. Finally, and importantly, we would like to express our sincere thanks to participants of the SEPAGES study.
The SEPAGES study group includes E. Eyriey, A. Licinia, A. Vellement (Groupe Hospitalier Mutualiste, Grenoble), I. Pin, P. Hoffmann, E. Hullo, C. Llerena (Grenoble University Hospital, La Tronche), X. Morin (Clinique des Cèdres, Echirolles), A. Morlot (Clinique Belledonne, Saint-Martin d’Hères), J. Lepeule, S. Lyon-Caen, C. Philippat, I. Pin, J. Quentin, V. Siroux, R. Slama (Inserm, CNRS, University Grenoble Alpes IAB research center).
Funding
This work was supported by the European Research Council under Grant N°311765-E-DOHaD; the European Community’s Seventh Framework Programme under Grant FP7/2007-206—N°308333-892 HELIX; the European Union’s Horizon 2020 research and innovation programme under Grants N° 874583 ATHLETE Project and N°825712 OBERON Project; the French Research Agency—ANR under Grants PAPER project ANR-12-PDOC-0029-01, SHALCOH project ANR-14-CE21-0007, ANR-15-IDEX-02 and ANR-15-IDEX5, GUMME project ANR-18-CE36-005 and ETAPE project ANR—EDeN project ANR -19-CE36-0003-01; the French Agency for Food, Environmental and Occupational Health & Safety—ANSES under Grants CNAP project EST-2016-121, PENDORE project EST-2016-121 and HyPAxE project EST-2019/1/039; the Plan Cancer under (Canc’Air project), the French Cancer Research Foundation Association de Recherche sur le Cancer—ARC, the French Endowment Fund AGIR for chronic diseases—APMC under Grants projects PRENAPAR and LCI-FOT, the French Endowment Fund for Respiratory Health, the French Fund—Fondation de France under Grants CLIMATHES—00081169 and SEPAGES 5—00099903; COBANET-Sepages project was supported by Anses and Ademe under Grants COBANET: Anses-PNR-EST-2015-1-022/Ademe-1594C0091and CRESPI: Anses-PNR-EST-2017-1-101/Ademe-1762C0021/ARS Ile de France 2018–2019: Pierre Lemire benefited from a PhD scholarship of the University of Paris-Sud/Paris-Saclay, France.
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Conceptualization, PL, VS and NLM; data curation, PL, AB, SL-C, RS, VS, EC, CDT, and NLM; formal analysis, PL and EC; funding acquisition, RS, VS and NLM; investigation, SL-C, AB, RS and VS; methodology, PL, VS and NLM; project administration, VS and NLM; software, PL; supervision, VS and NLM; validation, PL, VS and NLM; visualization, PL; writing—original draft, PL, VS and NLM; writing—review & editing, EC, SL-C, ES, AB, EPDS, CDT, RS, OD, VS and NLM. All authors have read and agreed to the published version of the manuscript.
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Ethics approval for the SEPAGES study was obtained from the Comité de Protection des Personnes Sud-Est V (approval number 13-CHUG-44). All Participants provided a signed informed consent form.
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Lemire, P., Chevallier, E., Lyon-Caen, S. et al. Association between household cleaning product profiles evaluated by the Ménag’Score® index and asthma symptoms among women from the SEPAGES cohort. Int Arch Occup Environ Health 95, 1719–1729 (2022). https://doi.org/10.1007/s00420-022-01860-w
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DOI: https://doi.org/10.1007/s00420-022-01860-w