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Cataract surgery utilization in Parkinson’s disease: the english longitudinal survey on ageing

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Abstract

Purpose

Older adults with Alzheimer’s disease are less likely to be offered cataract surgery than the general population, but these disparities have not been examined in the context of other neurodegenerative disorders such as Parkinson’s disease (PD).

Methods

Using data from the English Longitudinal Study on Ageing (ELSA), an ongoing, longitudinal population-based survey of older adults in England, we examined the relationship between PD and cataract surgery among adults 50 and older. We used logistic regression to measure the association between PD and history of cataract surgery at baseline. In longitudinal analyses of subjects with no history of cataract surgery at time of enrollment, we used semiparametric, discrete-time proportional hazards models to model the incidence of cataract surgery as a function of PD and other time-dependent covariates. Models were adjusted for demographic variables, self-reported comorbidities, and measures of daily activity limitation.

Results

We included data from 19,241 eligible ELSA respondents, of whom 231 (1.2%) reported a diagnosis of PD. PD was positively associated with a history of self-reported cataract surgery at baseline (OR 3.66, 95% CI: 2.55–5.26), but this did not remain significant after adjusting for confounders (OR 1.22, 95% CI: 0.75–1.98). Among subjects with no history of cataract surgery at baseline, PD was also not associated with incident cataract surgery (adjusted HR 1.32, 95% CI: 0.86–2.02).

Conclusion

Unlike Alzheimer’s disease, people with PD were no less likely to receive cataract surgery compared to those without PD.

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Acknowledgements

ELSA is funded by the National Institute on Aging (R01AG017644), and by UK Government Departments coordinated by the National Institute for Health and Care Research (NIHR).

Funding

This work was funded by the National Eye Institute (grant number K23 EY033438-02). ELSA is funded by the National Institute on Aging (R01AG017644), and by UK Government Departments coordinated by the National Institute for Health and Care Research (NIHR). The sponsor or funding organization had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Departments of Neurology, Ophthalmology, and Epidemiology, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr., Blockley 829, Philadelphia, PA, 19104, USA

    Angela L. Xu & Ali G. Hamedani

  2. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Ali G. Hamedani

  3. Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA

    Ali G. Hamedani

Authors
  1. Angela L. Xu
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  2. Ali G. Hamedani
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Contributions

Ms. Xu performed the statistical analysis and primarily drafted the manuscript. Dr. Hamedani conceived of the study, performed the statistical analysis, and critically reviewed the manuscript. Dr. Hamedani had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Corresponding author

Correspondence to Ali G. Hamedani.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the (place name of institution and/or national research committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The secondary analysis of de-identified, publicly available survey data was exempted from approval by the University of Pennsylvania Institutional Review Board.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Xu, A.L., Hamedani, A.G. Cataract surgery utilization in Parkinson’s disease: the english longitudinal survey on ageing. Graefes Arch Clin Exp Ophthalmol 262, 865–870 (2024). https://doi.org/10.1007/s00417-023-06314-8

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  • DOI: https://doi.org/10.1007/s00417-023-06314-8

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