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Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography

  • Retinal Disorders
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Abstract

Background

With FA and SD-OCT, different types of CNV in exudative AMD may be differentiated: type 1 CNV (within the sub-RPE space, typically corresponding to angiographically occult CNV), type 2 CNV (within the subretinal space, typically corresponding to angiographically classic CNV) and type 3 NV (intraretinal retinal angiomatous proliferation). OCT-angiography (OCT-A) is a new method to visualize vasculature based on flow characteristics. A correlation of type 1 and 2 CNV was performed.

Methods

Thirty-six eyes (17 type 1 CNV, 9 combined type 1 and 2 CNV, and 10 type 2 CNV) of 36 patients were examined by FA, SD-OCT and OCT-A. Standardized OCT-A segmentations were performed at the level of mid-choroid, choriocapillaris (CC), RPE and outer retina. On these images the size and demarcation of CNV lesions were classified: “not distinguishable”, “minor” or “sharp” demarcation. Furthermore, the size of the different CNV subtypes was determined and compared.

Results

Both types of CNV were visible in OCT-A. They could be detected on the slabs “mid-choroid”, “CC” and “RPE”. While type 1 CNV showed most often a minor demarcation from the surrounding vasculature, type 2 CNV showed nearly always a sharp demarcation. In addition, type 2 CNV extended into the slab “outer retina” and were much smaller than type 1 CNV.

Conclusions

Different types of CNV in exudative AMD can be visualized and differentiated with OCT-A. Type 1 CNV were larger with minor demarcation from the surrounding vasculature and were visible on the slab “mid-choroid”, “CC” and “RPE”. In contrast, type 2 CNV demonstrated a sharp demarcation from the surrounding vasculature reaching the slab “outer retina”.

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Authors and Affiliations

  1. Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany

    Marie-Louise Farecki, Matthias Gutfleisch, Henrik Faatz, Kai Rothaus, Britta Heimes, Georg Spital, Albrecht Lommatzsch & Daniel Pauleikhoff

Authors
  1. Marie-Louise Farecki
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  2. Matthias Gutfleisch
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  3. Henrik Faatz
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  4. Kai Rothaus
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  5. Britta Heimes
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  6. Georg Spital
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  7. Albrecht Lommatzsch
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  8. Daniel Pauleikhoff
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Correspondence to Daniel Pauleikhoff.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Farecki, ML., Gutfleisch, M., Faatz, H. et al. Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography. Graefes Arch Clin Exp Ophthalmol 255, 913–921 (2017). https://doi.org/10.1007/s00417-017-3588-y

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  • DOI: https://doi.org/10.1007/s00417-017-3588-y

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