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Pulse waveform analysis of optic nerve head circulation for predicting carotid atherosclerotic changes

  • Neurophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

A Correction to this article was published on 26 October 2021

This article has been updated

Abstract

Purpose

To evaluate the relationship between the parameters of pulse waveform analysis in the optic nerve head using laser speckle flowgraphy (LSFG) and intima-media thickness (IMT) and severity of carotid arterial plaque.

Design

Prospective and cross-sectional study.

Methods

One hundred seventy-six subjects were studied. Mean IMT and plaque score obtained from high-resolution B-mode ultrasound were evaluated. If mean IMT was 1 mm or greater, abnormal carotid artery thickening was diagnosed; if the plaque score exceeded 10, severe atherosclerosis was diagnosed. Blowout time and blowout score, which are parameters of pulse waveform analysis using LSFG, were evaluated. Logistic regression analyses determined the independent factors for abnormal carotid artery thickening and severe atherosclerosis. The cutoff levels for abnormal carotid artery thickening and severe atherosclerosis were analyzed using a conventional receiver operating characteristic (ROC) curve.

Results

Logistic regression analysis showed that blowout time and body mass index contributed independently to abnormal carotid artery thickening, and blowout score contributed independently to severe atherosclerosis. The ROC curve showed that sensitivity and specificity of the blowout time and blowout score were equivalent to or greater than those of other factors. The cutoff level of the blowout time for abnormal carotid artery thickening was 46.4; the cutoff level of the blowout score for severe atherosclerosis was 71.8.

Conclusions

Measurement of blowout time and blowout score in the optic nerve head by LSFG can be useful for evaluating mean IMT and plaque score, which are parameters of carotid atherosclerosis.

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Acknowledgments

The authors did not receive funds, sponsorship, or other support for this study. There are no conflicts of interest to report. No statistical consultation or assistance was used.

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Authors and Affiliations

  1. Department of Ophthalmology, Toho University Sakura Medical Center, Chiba, Japan

    Muramatsu Rina & Takatoshi Maeno

  2. Department of Ophthalmology, School of Medicine Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan

    Tomoaki Shiba & Yuichi Hori

  3. Cardiovascular Center, Toho University Sakura Medical Center, Chiba, Japan

    Mao Takahashi

Authors
  1. Muramatsu Rina
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  2. Tomoaki Shiba
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  3. Mao Takahashi
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  4. Yuichi Hori
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  5. Takatoshi Maeno
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Correspondence to Tomoaki Shiba.

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Rina, M., Shiba, T., Takahashi, M. et al. Pulse waveform analysis of optic nerve head circulation for predicting carotid atherosclerotic changes. Graefes Arch Clin Exp Ophthalmol 253, 2285–2291 (2015). https://doi.org/10.1007/s00417-015-3123-y

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  • DOI: https://doi.org/10.1007/s00417-015-3123-y

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