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Restoration of the photoreceptor outer segment and visual outcomes after macular hole closure: spectral-domain optical coherence tomography analysis

  • Retinal Disorders
  • Published:
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Abstract

Background

To evaluate the prognostic value of foveal microstructures as determined using spectral-domain optical coherence tomography (SD-OCT) in eyes with surgically closed macular holes (MHs).

Methods

Thirty eyes of 30 patients that underwent successful vitrectomy for idiopathic MHs were studied. Best-corrected visual acuity (BCVA) and SD-OCT images of the fovea were examined preoperatively and at 2 weeks, 1, 3, and 6 months postoperatively. The SD-OCT characteristics evaluated included MH diameter, external limiting membrane (ELM) defect diameter, photoreceptor inner/outer segment (IS/OS) junction defect diameter, the presence or absence of subretinal fluid (SRF), central foveal thickness (CFT), and outer foveal thickness (the distance between the ELM and the inner border of the retinal pigment epithelium). The correlations between SD-OCT parameters and BCVA were analyzed.

Results

The IS/OS junction defect diameter was most strongly correlated with BCVA at 2 weeks and 1 month postoperatively while outer foveal thickness showed the strongest correlation with BCVA at 3 and 6 months. Outer foveal thickness gradually increased over the follow-up period. Among the pre- and early postoperative quantitative parameters, the only significant predictors of BCVA at 6 months were the IS/OS junction defect diameter and outer foveal thickness at 2 weeks (p = 0.012, p = 0.018, respectively). Disrupted ELM at 2 weeks was also associated with significantly poorer BCVA at 6 months (p < 0.001).

Conclusions

An increase in outer foveal thickness, indicating photoreceptor outer segment restoration, is an important factor for visual recovery after MH surgery.

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The authors have no proprietary interest in the material used in this study.

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Authors and Affiliations

  1. Department of Ophthalmology, Kobe City Medical Center General Hospital, 4-6, Minatojima-Nakamachi, Chuo-ku, Kobe, 650-0046, Japan

    Masataka Shimozono, Akio Oishi, Masayuki Hata & Yasuo Kurimoto

  2. Department of Ophthalmology, Institute of Biomedical Research and Innovation Hospital, Kobe, Japan

    Akio Oishi & Yasuo Kurimoto

Authors
  1. Masataka Shimozono
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  2. Akio Oishi
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  3. Masayuki Hata
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  4. Yasuo Kurimoto
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Correspondence to Akio Oishi.

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The authors have full control of all primary data and agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review the data if requested.

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Shimozono, M., Oishi, A., Hata, M. et al. Restoration of the photoreceptor outer segment and visual outcomes after macular hole closure: spectral-domain optical coherence tomography analysis. Graefes Arch Clin Exp Ophthalmol 249, 1469–1476 (2011). https://doi.org/10.1007/s00417-011-1681-1

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  • DOI: https://doi.org/10.1007/s00417-011-1681-1

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