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Humoral immune response to p53 in malignant glioma

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Abstract

p53 immunoreactivity and humoral immune response to p53 were examined in 14 patients with malignant glioma, including 4 patients with leptomeningeal glioma cell dissemination. Twelve patients expressed p53 protein within the tumour tissue. p53 antibodies were detected in the serum in 2 of 14 patients but never in the cerebrospinal fluid (CSF). Soluble p53 protein was detected neither in serum nor in CSF of the glioma patients. CSF levels of the immunosuppressive cytokine, transforming growth factor (TGF)-β, were elevated in the glioma patients, including those with a humoral response to p53. These preliminary findings raise the possibility of systemic humoral immune responses to antigens, including mutant p53, expressed by glioma cells in the central nervous system.

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Authors and Affiliations

  1. Neurologische Klinik der Universität Tübingen, Hoppe-Seyler-Straße 3, D-72076, Tübingen, Germany

    Michael Weller, Marko Ständer, Martin Schabet & Johannes Dichgans

  2. Institute for Brain Research, University of Tübingen, Medical School, Tübingen, Germany

    Antje Bornemann & Richard Meyermann

Authors
  1. Michael Weller
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  2. Marko Ständer
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  3. Martin Schabet
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  4. Johannes Dichgans
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  5. Antje Bornemann
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  6. Richard Meyermann
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Correspondence to Michael Weller.

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Weller, M., Ständer, M., Schabet, M. et al. Humoral immune response to p53 in malignant glioma. J Neurol 245, 169–172 (1998). https://doi.org/10.1007/s004150050199

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  • DOI: https://doi.org/10.1007/s004150050199

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