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Central-peripheral sensory axonopathy in a juvenile case of Alpers-Huttenlocher disease

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Abstract.

Peripheral ataxia is reported in a juvenile case of Alpers-Huttenlocher disease (AHD). Neurophysiological and neuropathological investigations revealed a central-peripheral axonopathy, affecting the deep sensation carried by the peripheral nerve fibres and the posterior tracts of the cord, due to neuronal loss of the sensory ganglia. Involvement of the sensory pathways is regarded as a major feature of juvenile AHD.

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Authors and Affiliations

  1. Department of Neurological and Visual Sciences, Section of Clinical Neurology, Policlinico GB Rossi, P.le LA Scuro 1, 37134 Verona, Italy. alessandro.simonati@univr.it, , , , , , IT

    Alessandro Simonati, Massimiliano Filosto, Giuliano Tomelleri, Chiara Savio, Paola Tonin, Alberto Polo & Nicolò Rizzuto

Authors
  1. Alessandro Simonati
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  2. Massimiliano Filosto
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  3. Giuliano Tomelleri
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  4. Chiara Savio
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  5. Paola Tonin
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  6. Alberto Polo
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  7. Nicolò Rizzuto
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Additional information

Received: 28 October 2002, Received in revised form: 2 January 2003, Accepted: 15 January 2003

Present address: A. Polo, MD, Neurology Unit, Hospital of Piove di Sacco (PD), Italy

Correspondence to: A. Simonati, MD

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Simonati, A., Filosto, M., Tomelleri, G. et al. Central-peripheral sensory axonopathy in a juvenile case of Alpers-Huttenlocher disease. J Neurol 250, 702–706 (2003). https://doi.org/10.1007/s00415-003-1065-5

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  • DOI: https://doi.org/10.1007/s00415-003-1065-5

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