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Sequence variation of a variable short tandem repeat at the D18S535 locus

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Abstract

A short tandem repeat in the D18S535 locus was sequenced in 25 selected alleles. A total of 8 different alleles were found which can be designated according to the total number of repeats. This STR is a simple hypervariable STR consisting of blocks of (GATA) repeats with a basic sequence structure (GATA)1(GACA)1(GATA)1 (GAT)1(GATA)9–16. Population data showed that this is a highly polymorphic STR with a heterozygosity of more than 0.80, a simple structure and small size (130–158 bp) which makes this an interesting DNA polymorphism for forensic and genetic purposes.

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Authors and Affiliations

  1. Institute of Legal Medicine, Faculty of Medicine, c/San Francisco s/n, E-15705 Santiago de Compostela, Spain e-mail: apimlang@usc.es or e-mail: apimllar@usc.es Tel. +34-81-582327; Fax +34-81-580336, , , , , , ES

    M. V. Lareu, S. Barral, A. Salas & A. Carracedo

Authors
  1. M. V. Lareu
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  2. S. Barral
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  3. A. Salas
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  4. A. Carracedo
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Received: 17 November 1997 / Received in revised form: 24 March 1998

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Lareu, M., Barral, S., Salas, A. et al. Sequence variation of a variable short tandem repeat at the D18S535 locus. Int J Leg Med 111, 337–339 (1998). https://doi.org/10.1007/s004140050185

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  • DOI: https://doi.org/10.1007/s004140050185