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Chromatin’s thread to alternative splicing regulation

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Abstract

Intron removal (pre-mRNA splicing) is a necessary step for expression of most genes in higher eukaryotes. Alternative splice site selection is a prevalent mechanism that diversifies genome outputs and offers ample opportunities for gene regulation in these organisms. Pre-mRNA splicing occurs co-transcriptionally and is influenced by features in chromatin structure, including nucleosome density and epigenetic modifications. We review here the molecular mechanisms by which the reciprocal interplay between chromatin and RNA processing can contribute to alternative splicing regulation.

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Acknowledgments

We thank Miguel Beato, Luciano Di Croce, Roderic Guigó, Maria Paola Paronetto, and members of our laboratory for discussions and comments on the manuscript. CI was supported by a la Caixa PhD fellowship. Work in our lab is supported by Fundación Botín, Ministerio de Economía y Competitividad, and Consolider RNAREG.

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  1. Centre de Regulació Genòmica (CRG), Barcelona, Spain

    Camilla Iannone & Juan Valcárcel

  2. Universitat Pompeu Fabra, Barcelona, Spain

    Camilla Iannone & Juan Valcárcel

  3. Institució Catalana de Recerca i Estudis Avançats, Dr. Aiguader 88, 08003, Barcelona, Spain

    Juan Valcárcel

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  1. Camilla Iannone
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Correspondence to Juan Valcárcel.

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Iannone, C., Valcárcel, J. Chromatin’s thread to alternative splicing regulation. Chromosoma 122, 465–474 (2013). https://doi.org/10.1007/s00412-013-0425-x

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