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Genetic background and 227Thorium as risk factors in biologically based models for induction of bone cancer in mice

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Abstract

We explore the potential for the biologically based two-stage clonal expansion model to make statements about the influence of genetic factors on the steps in the model. We find evidence that the different susceptibility of BALB/C and CBA/Ca mice to bone cancer after 227Thorium injection may be mostly due to different promotional responses to radiation. In BALB/C × CBA/Ca back-crossed mice, we analyzed the specific contribution of two individual loci in the carcinogenic process. This analysis suggests that the two high- or low-risk alleles are acting on promotion or on the background parameters, but not on radiation-induced initiation. Taken together with the comparison of CBA/Ca and BALB/C mice, this hints at the possibility that the two loci are candidates for modifying radiation-induced promotion.

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Acknowledgments

This work was in part supported by the EU under contract number FI6R-CT-2003-508842 and by DoReMi.

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Author notes

  1. W. F. Heidenreich

    Present address: Institute for Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany

Authors and Affiliations

  1. Institute for Radiation Protection, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany

    W. F. Heidenreich

  2. Institute for Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany

    M. Rosemann

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  1. W. F. Heidenreich
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Correspondence to W. F. Heidenreich.

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Heidenreich, W.F., Rosemann, M. Genetic background and 227Thorium as risk factors in biologically based models for induction of bone cancer in mice. Radiat Environ Biophys 51, 179–185 (2012). https://doi.org/10.1007/s00411-012-0409-x

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  • DOI: https://doi.org/10.1007/s00411-012-0409-x

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