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Drug induced sleep endoscopy and simultaneous polysomnography to predict the effectiveness of mandibular advancement device in obstructive sleep apnea treatment

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Abstract

Purposes

To evaluate whether mandibular advancement device therapy is recommended in patients affected by obstructive sleep apnea.

Methods

In order to predict oral appliances therapy response, drug induced sleep endoscopy with cardio-respiratory polygraphy and mandibular advancement device simulator was carried out. Patients in which upper airway obstruction was resolved on all levels and AHI was normalized (< 5/h), were referred for oral appliance therapy. At 5 months follow up, a cardio-respiratory polygraphy with MAD was performed.

Results

36 patients who have evidence of resolution of UA collapse and AHI below 5 events per hour, were referred for MAD therapy. At follow up, the mean AHI decreased from 29.1 ± 13.1 to 3.3/h ± 1.9 (p < 0.001). All the patients were responders.

Conclusion

Combining the evaluation of drug induced sleep endoscopy and cardio-respiratory polygraphy data simultaneously during mandibular protrusion, has the potential to be a useful tool for prediction of MAD therapy response.

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Data availability

The datasets generated and/or analysed during the current study are not publicly available due to legal restrictions on releasing patients’ information to open publics, but are available from the corresponding author on reasonable request.

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Author information

Authors and Affiliations

  1. Centre for Medical Sciences, University of Trento, Trento, Italy

    Ottavio Piccin

  2. Division of Otolaryngology Head and Neck Surgery, S.Chiara Hospital, Trento, Italy

    Ottavio Piccin & Anna Bonsembiante

  3. Division of Otolaryngology Head and Neck Surgery, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy

    Irene Pelligra

  4. Unit of Orthodontics, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy

    Giulio Alessandri Bonetti

Authors
  1. Ottavio Piccin
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  2. Irene Pelligra
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  3. Giulio Alessandri Bonetti
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  4. Anna Bonsembiante
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Contributions

Ottavio Piccin and Irene Pelligra designed the study, analyzed and interpreted data, and drafted the manuscript. Giulio A Bonetti, Anna Bonsembiante and Irene Pelligra collected the data and revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ottavio Piccin.

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Ethics approval and consent to participate

Ethical approval was obtained from the local Ethical Committee. Informed consent was obtained from the patients before inclusion in the study.

Conflict of interest

The authors declare that they have no competing interests.

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Piccin, O., Pelligra, I., Bonetti, G.A. et al. Drug induced sleep endoscopy and simultaneous polysomnography to predict the effectiveness of mandibular advancement device in obstructive sleep apnea treatment. Eur Arch Otorhinolaryngol 281, 6693–6698 (2024). https://doi.org/10.1007/s00405-024-09017-w

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  • DOI: https://doi.org/10.1007/s00405-024-09017-w

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