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Blood–labyrinth barrier breakdown in Meniere’s disease

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

We compared the signal intensity ratio (SIR) of the cochlear basal turn between Meniere's disease and healthy controls to investigate potential damage of the blood–labyrinth barrier in Meniere's disease.

Methods

Thirty patients diagnosed with unilateral definite Meniere's disease and 24 healthy controls were enrolled. 3D-FLAIR scan was conducted to assess the grades of endolymphatic hydrops in Meniere's patients while measuring the SIR of cochlear basal turns in both groups. The differences of bilateral SIR between Meniere's disease and healthy control were compared, and the correlation between the SIR on affected ear in Meniere's disease and the grades of cochlear and vestibular hydrops were analyzed.

Results

SIR of affected ear in Meniere's disease exhibited significant increase compared to that of unaffected ear. No significant difference was observed in SIR between the two ears in the healthy control. Furthermore, the SIR of unaffected side in Meniere's disease was higher than that of both ears in healthy controls. The SIR in affected ear of Meniere's disease exhibited positive correlation with hydrops in both cochlea and vestibula.

Conclusion

The permeability of blood–labyrinth barrier is increased in Meniere's disease, in combination with the typical criteria of Meniere's disease it may be a good biological marker. Destruction of blood–labyrinth barrier may be one of the causes of endolymphatic hydrops in Meniere's disease.

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Data availability statement

All authors make sure that all data and materials as well as software application or custom code support their published claims and comply with field standards.

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Funding

No funding was received to assist with the preparation of this manuscript.

Author information

Author notes

  1. Hongjian Liu and Meiyun Wang are shared corresponding author.

Authors and Affiliations

  1. Department of Medical Imaging, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, 7 Weiwu Road, Zhengzhou, 450000, China

    Weidong Zhang, Jiapei Xie & Meiyun Wang

  2. Laboratory of Brain Science and Brain-Like Intelligence Technology, Institute for Integrated Medical Science and Engineering, Henan Academy of Sciences, Zhengzhou, China

    Meiyun Wang

  3. Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China

    Jiapei Xie

  4. Department of Otorhinolaryngology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, 7 Weiwu Road, Zhengzhou, 450000, China

    Hongjian Liu

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  1. Weidong Zhang
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by WZ and JX. The first draft of the manuscript was written by WZ and review and editing: MW and HL. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Meiyun Wang.

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Conflict of interest

The authors have no competing interests to declare that are relevant to the content of this article.

Ethical approval

This study was approved by the Medical Ethics Committee of Henan Provincial People's Hospital (2022-174).

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Informed consent was obtained from all individual participants included in the study.

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Zhang, W., Xie, J., Liu, H. et al. Blood–labyrinth barrier breakdown in Meniere’s disease. Eur Arch Otorhinolaryngol 281, 2327–2332 (2024). https://doi.org/10.1007/s00405-023-08353-7

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  • DOI: https://doi.org/10.1007/s00405-023-08353-7

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