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A prognostic value of estimated pulse wave velocity in idiopathic sudden sensorineural hearing loss

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Arterial stiffness, represented by estimated pulse wave velocity (ePWV), is the independent surrogate marker for cardiovascular event. The aim of the study was to investigate the significance of ePWV in the treatment outcome of idiopathic sudden sensorineural hearing loss (SSNHL).

Methods

One hundred and ten patients with idiopathic SSNHL who hospitalized between April 2019 and March 2022 were evaluated. Arterial stiffness was calculated with formula for ePWV and other cardiovascular parameters of body mass index (BMI), and serum lipid level was determined. All patients received systemic high-dose steroid therapy and intratympanic steroid injections as a salvage management. Treatment outcome was assessed at 6 months after treatment, and classified as recovery and nonrecovery groups according to hearing recovery.

Results

The initial pure-tone hearing threshold was 72.6 ± 23.8 dB and final hearing threshold was 52.63 ± 31.10 dB. After treatment, 60 (54.5%) patients included in recovery group and other 50 (45.5%) were classified as nonrecovery group. Age, days of onset to treatment, BMI, waist circumference, and ePWV were higher in the nonrecovery group compared to recovery group in univariate analysis (p = 0.039, p = 0.049, p = 0.003, p = 0.004, p = 0.007, respectively). In multivariate analysis, days of onset to treatment, BMI, and ePWV were associated with recovery (p = 0.030, p = 0.007, p = 0.022).

Conclusion

Higher ePWV, a measure of arterial stiffness, was associated with a poor hearing recovery of SSNHL.

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Data Availability

The data supporting the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant number: HI21C1574).

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, College of Medicine, Hanyang University, 222-Wangshimni-ro, Seongdong-gu, Seoul, 133-792, Republic of Korea

    Hee Won Seo, Seok Hwa Ko, Jae Ho Chung, Hayoung Byun & Seung Hwan Lee

  2. Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Guri, Republic of Korea

    Jeong-Hun Shin

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  1. Hee Won Seo
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Correspondence to Jae Ho Chung.

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This study was approved by the Institutional Review Board of Hanyang University Guri Hospital (IRB FILE No: 2022-06-036.)

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Seo, H.W., Ko, S.H., Chung, J.H. et al. A prognostic value of estimated pulse wave velocity in idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 281, 1745–1751 (2024). https://doi.org/10.1007/s00405-023-08289-y

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  • DOI: https://doi.org/10.1007/s00405-023-08289-y

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