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Association of cervical vestibular-evoked myogenic potential tuning property test results with MRI findings of endolymphatic hydrops in Meniere’s disease

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To examine the concordance between cervical vestibular-evoked myogenic potential (cVEMP) tuning property test results and MRI findings of endolymphatic hydrops (EH).

Methods

Fourteen subjects (age 24–76 years) that had been diagnosed with unilateral definite Meniere’s disease (MD) (N = 8) or unilateral probable MD (N = 6) were enrolled. All of the subjects underwent cVEMP tests (using 500 Hz and 1000 Hz tone bursts), pure-tone audiometry, and gadolinium-enhanced 3 T-MRI. To examine tuning properties of cVEMP, the 500–1000 Hz amplitude ratio was calculated as the SLOPE. The results of the cVEMP tuning property test results were compared with EH-related MRI findings.

Results

EH positivity in both the cochlea and vestibule on MRI was observed in 7 of the 8 affected ears of definite MD and 3 of the 6 affected ears of probable MD, although it was only in one of the 14 unaffected ears. EH(+) or no response (NR) in cVEMP tuning property test was significantly associated with EH positivity on MRI, while EH(-) in the cVEMP tuning property test was significantly associated with EH-negativity on MRI (p = 0.0016 Fisher’s exact test test).

Conclusion

EH(+) or NR in the cVEMP tuning property test correspond well to EH positivity in the MRI findings. The cVEMP tuning property test is useful for screening and following up EH.

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Funding

This study was partially supported by Grants-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (15K10764, 19K09856) and a grant from AMED (grant number: JP19dk0310092).

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Authors and Affiliations

  1. Department of Otolaryngology, Teikyo University School of Medicine Mizonokuchi Hospital, 5-1-1 Futago, Takatsu-ku, Kawasaki, 213-8507, Japan

    Toshihisa Murofushi & Masahito Tsubota

  2. Department of Radiology, Ochanomizu Surugadai Clinic, Tokyo, Japan

    Yasuhisa Kanai & Hideho Endo

  3. Department of Otolaryngology, Toho University School of Medicine Sakura Medical Center, Sakura, Japan

    Munetaka Ushio

Authors
  1. Toshihisa Murofushi
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  2. Masahito Tsubota
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  3. Yasuhisa Kanai
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  4. Hideho Endo
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  5. Munetaka Ushio
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Corresponding author

Correspondence to Toshihisa Murofushi.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from each subject. This study was approved by the ethics committee of Teikyo University.

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Murofushi, T., Tsubota, M., Kanai, Y. et al. Association of cervical vestibular-evoked myogenic potential tuning property test results with MRI findings of endolymphatic hydrops in Meniere’s disease. Eur Arch Otorhinolaryngol 278, 3267–3273 (2021). https://doi.org/10.1007/s00405-020-06410-z

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  • DOI: https://doi.org/10.1007/s00405-020-06410-z

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