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MarginProbe© reduces the rate of re-excision following breast conserving surgery for breast cancer

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

A positive margin status after breast conserving surgery (BCS) is one of the strongest predictors for local recurrence of intraductal (DCIS) and invasive carcinoma. As much as 20–50 % of patients with BCS need to undergo a second operation to receive free margins. In this study we tested the clinical performance of MarginProbe© (Dune Medical Devices, Paoli, PA, USA), a device for the intraoperative evaluation of surgical margins.

Methods

A prospective clinical study was performed: The device was utilized in BCS of 150 patients treated at a single facility from November 2012 to June 2013. The re-excision rate was compared to the re-excision rate of a historical group of 172 patients treated with BCS at the same hospital without the application of the device. We analyzed whether the results of MarginProbe© are affected by the morphology, grading, size of the tumor, breast density, age, BMI or the use of marker-wires.

Results

The application of MarginProbe© resulted in an overall decreased re-excision rate of 14.6 %. In the subgroup of DCIS the re-excision rate was reduced from 61.7 to 23.1 %. In the subgroup of invasive lobular carcinomas the re-excision rate decreased from 37.0 to 19.0 %. MarginProbe© results were not affected by grading, tumor size, breast density, age, BMI or marker-wire application.

Conclusion

MarginProbe© detects positive margins in invasive carcinoma, DCIS as well as in invasive lobular carcinoma. The device decreases the re-excision rate after BCS significantly. It does not interfere with any of the factors we examined.

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Acknowledgments

Unrestricted grant from Dunne Medical Corp. for scientific work. Prof. Blohmer got honoraria for presentations from Dunne Medical Corp.

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Authors and Affiliations

  1. Breast Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Jens-Uwe Blohmer, Janina Kueper, Jessica Groß, Ragna Völker & Anna Machleidt

  2. Department of Gynecology and Breast Center, Sankt-Gertrauden Hospital, Paretzer Str. 12, 10713, Berlin, Germany

    Jens-Uwe Blohmer, Julia Tanko, Jessica Groß, Ragna Völker & Anna Machleidt

Authors
  1. Jens-Uwe Blohmer
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  2. Julia Tanko
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  3. Janina Kueper
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  4. Jessica Groß
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  5. Ragna Völker
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  6. Anna Machleidt
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Correspondence to Anna Machleidt.

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Conflict of interest

The author declares that there is no actual or potential conflict of interest in relation to this article exists apart from what is mentioned under acknowledgements.

Ethical standards

This prospective study was approved by our institution’s ethical committee. Authors had full control of all primary data and agree to allow the Journal to review the data if requested.

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Blohmer, JU., Tanko, J., Kueper, J. et al. MarginProbe© reduces the rate of re-excision following breast conserving surgery for breast cancer. Arch Gynecol Obstet 294, 361–367 (2016). https://doi.org/10.1007/s00404-016-4011-3

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  • DOI: https://doi.org/10.1007/s00404-016-4011-3

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