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Association between osteocalcin and metabolic syndrome in postmenopausal women

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objectives

Undercarboxylated osteocalcin (ucOC) has been proved as a regulator of glucose and fat mass in an animal model. This study examined the association between osteocalcin and metabolic syndrome (MetS) in postmenopausal women.

Methods

We selected 135 postmenopausal women and determined anthropometric values [waist-hip ratio (WHR), visceral fat area (VFA), body fat mass (BFM), and skeletal muscle mass (SMM)], the lipid profile, fasting plasma glucose (FPG), insulin, high-sensitivity C-reactive protein (hs-CRP), homeostasis model assessment of insulin resistance (HOMA-IR), serum leptin and adiponectin level, and serum tOC and ucOC level.

Results

There were 52 postmenopausal women in the MetS group. After adjusting for age and years since menopause, ucOC was negatively correlated with WHR, VFA, BFM, triglyceride, fasting insulin, HOMA-IR, and serum leptin and was positively correlated with serum adiponectin. The odds ratio for MetS was significantly lower in the highest quartile than the lowest quartile after adjusting for age, years since menopause, and BMI. In multiple regression analysis, serum leptin and HOMA-IR were the most important predictors of the independent variables that affect serum ucOC.

Conclusion

ucOC showed an inverse correlation with markers of insulin resistance, central obesity, and the presence of MetS in postmenopausal women and appears to protect against MetS. Further large-scale clinical and experimental studies are needed to clarify the potential of ucOC as a predictor of MetS in postmenopausal women.

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Conflict of interest

The authors have stated explicitly that there are no conflicts of interest in connection with this article.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 431-796, Korea

    Suk Woo Lee

  2. Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea

    Hyun Hee Jo, Mee Ran Kim & Jang Heub Kim

  3. Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, St. Vincent Hospital, 93 Jungbu-daero, Ji-dong, Paldal-gu, Suwon, Gyeonggi-do, 442-723, Korea

    Young Oak You

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  1. Suk Woo Lee
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Correspondence to Young Oak You.

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Lee, S.W., Jo, H.H., Kim, M.R. et al. Association between osteocalcin and metabolic syndrome in postmenopausal women. Arch Gynecol Obstet 292, 673–681 (2015). https://doi.org/10.1007/s00404-015-3656-7

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  • DOI: https://doi.org/10.1007/s00404-015-3656-7

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