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High-risk human papillomavirus among HIV-infected women with normal cervical cytology: a pilot study in Jos, Nigeria

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Cervical cancer is strongly linked to high-risk human papillomavirus (HR-HPV) and is typically preceded by cytological abnormalities. Less is known in patients with normal cervical cytology (NCC). We investigated the epidemiology of HR-HPV among HIV-infected women with NCC.

Methodology

We conducted a cross-sectional study between January and June 2011 among HIV-infected women with NCC at an adult HIV clinic in Jos, Nigeria. Cervical sampling and analysis for HR-HPV by hybrid capture (HC2) with signal amplification was done to determine presence of one or more of the following HR-HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68. Epidemiologic factors associated with HR-HPV were determined using bivariate statistics and multivariate logistic regression.

Results

We evaluated 103 HIV-infected women with Pap cytology. The median age of the women was 32 years (range 21–49). Ninety-seven (94.2 %) had NCC. Cervical samples for HR-HPV DNA testing were available from 89/97 (91.8 %) of the HIV-infected women with NCC. Of the 89 women with cervical samples for HR-HPV DNA testing, 40 (44.9 %) had detectable HR-HPV by HC2 giving a HR-HPV prevalence of 44.9 % (95 % CI 33.9–55.5 %). Age < 30 years was associated with HR-HPV (OR 2.69 [95 % CI 1.05–6.91, p = 0.039]) while history of previous abortion showed an inverse association with HR-HPV (OR 0.33[95 % CI 0.15–0.94, p = 0.039]).

Conclusion

The prevalence of HR-HPV is seemingly high among HIV-infected women with NCC in our clinical setting. These data provide support for further investigation of the clinical implications of positive HR-HPV among HIV-infected women with NCC report in cervical cancer prevention programs in Nigeria.

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Acknowledgments

This study was funded through a seed award on completion of a Master of Science in Clinical Investigation training at Northwestern University, Chicago sponsored by the Fogarty Northwestern University AIDS International Training and Research Program (NU-AITRP), grant #-ID43TW007995-01A1. This work was funded in part by the US Department of Health and Human Services, Health Resources and Services Administration [U51HA02522-01-01]. The contents are solely the responsibility of the authors and do not represent the official views of the funding institutions.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Jos, Jos, Nigeria

    Jonah Musa & Atiene S. Sagay

  2. Department of Medicine and Center for Global Health, Northwestern University, Chicago, IL, USA

    Babafemi Taiwo, Chad Achenbach, Baiba Berzins & Robert L. Murphy

  3. Department of Pathology, University of Jos, Jos, Nigeria

    Silas Olugbenga

  4. Department of Medicine, University of Jos, Jos, Nigeria

    John A. Idoko

  5. Harvard School of Public Health, Boston, MA, USA

    Phyllis J. Kanki

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  1. Jonah Musa
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  2. Babafemi Taiwo
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Correspondence to Jonah Musa.

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Musa, J., Taiwo, B., Achenbach, C. et al. High-risk human papillomavirus among HIV-infected women with normal cervical cytology: a pilot study in Jos, Nigeria. Arch Gynecol Obstet 288, 1365–1370 (2013). https://doi.org/10.1007/s00404-013-2885-x

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  • DOI: https://doi.org/10.1007/s00404-013-2885-x

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