Abstract
Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The present study is to investigate whether FCER1A polymorphisms are associated with the risk of CSU, and to determine whether these polymorphisms influence the therapeutic efficacy of nonsedating H1-antihistamines. 191 CSU patients treated by nonsedating H1-antihistamines monotherapy (including desloratadine, mizolastine or fexofenadine) were prospectively enrolled in this study. The response to antihistamines monotherapy was assessed by urticaria activity score (UAS7) after 4 weeks of treatment. FCER1A rs2298805, rs10908703 and rs2494262 genotypes were determined by Sequenom Mass Array technology or direct sequencing. There was significant difference in the allele frequency of rs2298805A between CSU patients and 177 healthy subjects (5.3 vs 10.2 %, P = 0.012, OR = 0.491, 95 % CI 0.278–0.865), and also significant difference in the allele frequency of rs2298805A between effective and ineffective groups (7.5 vs 1.0 %, P = 0.015, OR = 8.328, 95 %CI 1.1–63.039). In addition, rs2298805 polymorphism was significantly associated with total serum IgE concentrations (P = 0.011). There were no differences in the rs10908703 and rs2494262 either between CSU patients and healthy controls, or between effective and ineffective groups. These data suggest that rs2298805 might be associated with risk for CSU and the therapeutic efficacy of nonsedating H1-antihistamines in Chinese patients with CSU.
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Acknowledgments
We appreciate Dr. Kyle R. Convington (Human Genome Sequencing Center, Baylor College of Medicine, TX 77030, USA) for revising this paper. This work was supported by grants from the National Natural Science Foundation of China (81001217 to Jie Li, 81225013 and 81430075 to Xiang Chen), Graduate Innovation Project in Central south university of Hunan Province (2013zzts086 to AiyuanGuo) and Science and Technology Project of Hunan Province (2014SK3108 to Jie Li).
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All the authors declare that they have no financial competing interests.
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Guo, A., Zhu, W., Zhang, C. et al. Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients. Arch Dermatol Res 307, 183–190 (2015). https://doi.org/10.1007/s00403-014-1525-z
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DOI: https://doi.org/10.1007/s00403-014-1525-z