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Promoter polymorphisms of the HLA-G gene, but not the HLA-E and HLA-F genes, is associated with non-segmental vitiligo patients in the Korean population

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Abstract

The aim of this study was to determine whether or not promoter polymorphisms of the class I major histocompatibility complex (HLA-E, HLA-F, and HLA-G) are associated with susceptibility to vitiligo. To identify a possible association with vitiligo, 241 patients with non-segmental vitiligo (NSV) and 395 healthy controls were recruited in this study. Three promoter single nucleotide polymorphisms (SNPs; rs1264459 of HLA-E, rs9258170 of HLA-F, and rs1736936 of HLA-G) were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and direct sequencing. Multiple logistic regression models (co-dominant 1, co-dominant 2, dominant, recessive, and log-additive models) were applied for odds ratios (ORs), 95% confidence intervals (CIs), and P values. To obtain the defined results, P values were recalculated by a Bonferroni correction. After the Bonferroni correction, the genotype of the SNP (rs1736936) of HLA-G was shown to have significant association with NSV (P = 0.045 in the recessive model). The genotype frequencies of the HLA-G SNP (rs1736936) had a significant correlation with the age of onset of NSV (P = 0.016 in the co-dominant 1 model and P = 0.027 in the dominant model). Our results suggest that HLA-G, but not HLA-E and HLA-F, may be associated with susceptibility to NSV in the Korean population.

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Conflict of interest

None declared.

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Authors and Affiliations

  1. Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea

    Su Kang Kim, Mi Sook Hong & Joo-Ho Chung

  2. Department of Dermatology, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702, Republic of Korea

    Min Kyung Shin & Mu-Hyoung Lee

  3. Department of Clinical Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea

    Yoon Kyung Uhm

Authors
  1. Su Kang Kim
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  2. Mi Sook Hong
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  3. Min Kyung Shin
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  4. Yoon Kyung Uhm
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  5. Joo-Ho Chung
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  6. Mu-Hyoung Lee
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Corresponding author

Correspondence to Mu-Hyoung Lee.

Additional information

S. K. Kim and M. S. Hong contributed equally to this work.

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Kim, S.K., Hong, M.S., Shin, M.K. et al. Promoter polymorphisms of the HLA-G gene, but not the HLA-E and HLA-F genes, is associated with non-segmental vitiligo patients in the Korean population. Arch Dermatol Res 303, 679–684 (2011). https://doi.org/10.1007/s00403-011-1160-x

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  • DOI: https://doi.org/10.1007/s00403-011-1160-x

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