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Caveolin-1 in meningiomas: expression and clinico-pathological correlations

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Abstract

Caveolin-1 (Cav-1) protein has been documented in several neoplasms with a controversial role in cell proliferation, tumour development and progression. The aim of the present study was to investigate the Cav-1 immunohistochemical expression in human meningiomas. Sixty-two cases, classified as 11 meningothelial (17%), 12 transitional (19%), 5 fibrous (8%), 3 microcystic (5%), 3 secretory (5%), 1 clear cell (2%), 1 chordoid (2%) and 26 (42%) atypical meningiomas, were selected from our pathological files. Clinico-pathological data, including Ki-67 values and survival data were also available. Ten leptomeningeal samples were utilized as normal tissue control. For each case, a polyclonal antibody against Cav-1 was applied and an intensity distribution (ID) score was determined. The Cav-1 immunoexpression was found in 95% of meningiomas with a variable ID score, while only minimal, not uniform, reactivity was noted in non-neoplastic meninges. Of note, higher Cav-1 ID score was significantly correlated with tumour site, Simpson’s grade, histological type, higher histologic grade, Ki-67 labelling index ≥ 4% and clinical course. Kaplan–Meier curves demonstrated a significantly worse survival in patients with higher Cav-1 ID score, Ki-67 ≥ 4% and 2–3 Simpson grade. Multivariate analysis indicated that only Ki-67 was an independent prognostic factor. Increased immunoexpression of the Cav-1 seems to be associated with the biological aggressiveness of meningiomas, reflecting a worse prognosis.

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Authors and Affiliations

  1. Dipartimento di Patologia Umana, Università degli Studi di Messina, Messina, Italy

    V. Barresi, E. Vitarelli, G. Giuffrè, G. Tuccari & G. Barresi

  2. UU.OO. di Anatomia Patologica, Presidio Ospedaliero “Bufalini” di Cesena, Messina, Italy

    S. Cerasoli

  3. UU.OO. di Neurochirurgia, Presidio Ospedaliero “Bufalini” di Cesena, Messina, Italy

    G. Paioli & G. Guiducci

  4. Pad D- Policlinico Universitario G. Martino, Via Consolare Valeria, 98125, Messina, Italy

    V. Barresi

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  1. V. Barresi
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  2. S. Cerasoli
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Correspondence to V. Barresi.

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Dedicated to Professor Dazio Batolo on the occasion of his retirement.

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Barresi, V., Cerasoli, S., Paioli, G. et al. Caveolin-1 in meningiomas: expression and clinico-pathological correlations. Acta Neuropathol 112, 617–626 (2006). https://doi.org/10.1007/s00401-006-0097-1

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  • DOI: https://doi.org/10.1007/s00401-006-0097-1

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