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Release of cationic drugs from loaded clay minerals

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Abstract

The adsorption of promethazine chloride [10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride (1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature of the human body (37 ± 0.5 °C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage, exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution rate.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University of Szeged 6720 Szeged, Eötvös u. 6, Hungary e-mail: fejeri@pharma.szote.u-szeged.hu Tel: +36-62-545571; Fax: +36-62-545571, , , , , , HU

    I. Fejér, M. Kata & I. Erös

  2. Department of Physical Chemistry University of Szeged, 6720 Szeged Rerrich Béla tér 1, Hungary, , , , , , HU

    O. Berkesi

  3. Department of Colloid Chemistry University of Szeged, 6720 Szeged Rerrich Béla tér 1, Hungary, , , , , , HU

    I. Dékány

Authors
  1. I. Fejér
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  2. M. Kata
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  3. I. Erös
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  4. O. Berkesi
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  5. I. Dékány
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Received: 20 January 2001 Accepted: 8 March 2001

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Fejér, I., Kata, M., Erös, I. et al. Release of cationic drugs from loaded clay minerals. Colloid Polym Sci 279, 1177–1182 (2001). https://doi.org/10.1007/s003960100527

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  • DOI: https://doi.org/10.1007/s003960100527

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