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Templated nucleation of hybrid iron oxide nanoparticles on polysaccharide nanogels

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Abstract

Novel organic–inorganic hybrid nanoparticles consisting of polymer–hydrogel nanoparticles (nanogels) and iron oxide were developed for potential biomedical applications. Hybrid nanoparticles were prepared by a simple procedure using polysaccharide nanogels as a reactive site for iron oxide formation. The hybrid nanoparticles have a narrow size distribution with a diameter of approximately 30 nm and show high colloidal stability. These nanohybrid particles could be used as a contrast medium for magnetic resonance imaging or for magnetic hyperthermia therapy.

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Acknowledgments

This work was supported by Grants-in-Aid for Scientific Research (no. 20107011 and no. 23107510) in the Innovative Area “Fusion Materials” (Area No. 2206) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT).

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Authors and Affiliations

  1. Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan

    Kiyofumi Katagiri

  2. Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan

    Kiyofumi Katagiri, Keiko Ohta & Kunihito Koumoto

  3. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101-0062, Japan

    Kei Kurosu & Yoshihiro Sasaki

  4. Graduate School of Engineering, Kyoto University, Kyoto daigaku, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan

    Yoshihiro Sasaki & Kazunari Akiyoshi

  5. ERATO, Japan Science and Technology Agency (JST), Kyoto daigaku, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan

    Kazunari Akiyoshi

Authors
  1. Kiyofumi Katagiri
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  2. Keiko Ohta
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  3. Kunihito Koumoto
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  4. Kei Kurosu
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  5. Yoshihiro Sasaki
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  6. Kazunari Akiyoshi
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Correspondence to Kiyofumi Katagiri.

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Katagiri, K., Ohta, K., Koumoto, K. et al. Templated nucleation of hybrid iron oxide nanoparticles on polysaccharide nanogels. Colloid Polym Sci 291, 1375–1380 (2013). https://doi.org/10.1007/s00396-012-2868-7

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  • DOI: https://doi.org/10.1007/s00396-012-2868-7

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