Abstract
A series of amphiphilic graft copolymers based on polyaspartamide were synthesized by a successive aminolysis reaction of polysuccinimide using 2-diisopropylaminoethyl (DIP) and laurylamine as a pH sensitive and hydrophobic group, respectively. The pH-dependent self-assembly behavior of the aqueous copolymer solution was investigated. Nano-aggregation occurred at a pH in the vicinity of the pKa of the DIP group, which was induced by a hydrophilic–hydrophobic shift of the DIP group in solution. The mean diameter of the nano-aggregate could be modulated by changing the composition of both pendants. The mean diameter of the nanoparticles increased with increasing solution pH from 6.5 to 8. At pH 8, the mean diameter of the nanoparticles increased rapidly at the temperature above 45 °C, probably due to the change in hydrophilic–hydrophobic balance of the pH-sensitive DIP moiety. The dissolution of paclitaxel (PTX) into this amphiphilic nanoparticle was attempted and the pH-dependent release behavior was examined with the stability study of the particle. The results showed significantly faster release of PTX at pH 6.5, which is a tumoral acidic pH, than in a neutral physiological pH. These thermo- and pH-sensitive polyaspartamide derivatives have potential use as a tumor-targeting delivery.
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Ballauff M, Lu Y (2007) Polymer 48:1815
Schmaljohann D (2006) Adv Drug Deliv Rev 58:1655
Park JH, Lee S, Kim JH, Park K, Kim K, Kwon IC (2008) Prog Polym Sci 33:113
Rapoprt N (2007) Prog Polym Sci 32:962
Lee ES, Gao Z, Bae YH (2008) J Control Release 132:164
Bae Y, Kataoka K (2009) Adv Drug Deliv Rev 61:768
Haradaa A, Kataoka K (2006) Prog Polym Sci 31:949
Kwon GS, Okano T (1996) Adv Drug Deliv Rev 21:107
Matsumura Y, Maeda H (1986) Cancer Res 46:6387
Duncan R (1999) Pharm Sci Technol Today 2:441
Yin H, Lee ES, Kim D, Lee KH, Oh KT, Bae YH (2008) J Control Release 126:130
Oh KT, Lee ES, Kim D, Bae YH (2008) J Control Release 126:130
Min KH et al (2010) J Control Release. doi:10.1016/j.jconrel.2010.02.024
Ko J et al (2007) J Control Release 123:109
Liu S, Weaver JVM, Tang Y, Billinghan NC, Armes SP (2002) Macromolecules 35:6121
Vamvakaki M, Unali GF, Bütün V, Boucher S, Robinson KL, Billinghan NC, Armes SP (2001) Macromolecules 34:6839
Bütün V, Armes SP, Billinghan NC (2001) Polymer 42:5993
Gillies ER, Frechet JM (2004) J Pure Appl Chem 76:1295
Toncheva V, Schacht E, Ng SY, Barr J, Heller J (2003) J Drug Target 11:345
Yoo HS, Lee EA, Park TG (2002) J Control Release 82:17
Chen W, Meng F, Li F, Ji SJ, Zhong Z (2009) Biomacromolecules 10:1727
We DC, Liu Y, He CB (2008) Macromolecules 41:18
Obst M, Steinbüchel A (2004) Biomacromolecules 5:1166
Giammona G, Pitarresi G, Cavallaro G, Carlisi B, Craparo EF, Mandracchia DJ (2006) Drug Del Sci Tech 16:77
Pitarresi G, Pierro P, Palumbo FS, Tripodo G, Giammona G (2006) Biomacromolecules 7:1302
Yang SR, Kim SB, Joe CO, Kim JD (2008) J Biomed Mater Res A 86A:137
Seo K, Kim JD, Kim D (2008) J Biomed Mater Res A 90A:478
Craparo EF, Cavallaro G, Bondi ML, Mandracchia D, Giammona G (2006) Biomacromolecules 7:3083
Moon JR, Kim BS, Kim JH (2006) Bull Korean Chem Soc 27:981
Moon JR, Kim JH (2006) Bull Korean Chem Soc 27:1981
Bach QV, Moon JR, Kim JH (2008) J Appl Polym Sci 107:509
Moon JR, Park YH, Kim JH (2009) J Appl Polym Sci 111:998
Moon JR, Kim JH (2008) Macromol Res 16:489
Moon JR, Kim JH (2010) Polym Int 59:630
Nakanishi M, Park JS, Jang WD, Oba M, Kataoka K (2007) React Funct Polym 67:1361
Shim WS, Kim SW, Choi EK, Park HJ, Kim JS, Lee DS (2006) Macromol Biosci 6:179
Nguyen MK, Park DK, Lee DS (2009) Biomacromolecules 10:728
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Moon, J.R., Kim, M.W., Kim, D. et al. Synthesis and self-assembly behavior of novel polyaspartamide derivatives for anti-tumor drug delivery. Colloid Polym Sci 289, 63–71 (2011). https://doi.org/10.1007/s00396-010-2307-6
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DOI: https://doi.org/10.1007/s00396-010-2307-6