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Ischemic postconditioning: experimental models and protocol algorithms

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Abstract

Ischemic postconditioning, a simple mechanical maneuver at the onset of reperfusion, reduces infarct size after ischemia/reperfusion. After its first description in 2003 by Zhao et al. numerous experimental studies have investigated this protective phenomenon. Whereas the underlying mechanisms and signal transduction are not yet understood in detail, infarct size reduction by ischemic postconditioning was confirmed in all species tested so far, including man. We have now reviewed the literature with focus on experimental models and protocols to better understand the determinants of protection by ischemic postconditioning or lack of it. Only studies with infarct size as unequivocal endpoint were considered. In all species and models, the duration of index ischemia and the protective protocol algorithm impact on the outcome of ischemic postconditioning, and gender, age, and myocardial temperature contribute.

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Authors and Affiliations

  1. Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Germany

    Andreas Skyschally, Patrick van Caster, Rainer Schulz & Gerd Heusch

  2. 2nd University Department of Cardiology Medical School, Attikon General Hospital, University of Athens, Athens, Greece

    Efstathios K. Iliodromitis & Dimitrios T. Kremastinos

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  1. Andreas Skyschally
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  2. Patrick van Caster
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  3. Efstathios K. Iliodromitis
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  4. Rainer Schulz
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  5. Dimitrios T. Kremastinos
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  6. Gerd Heusch
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Correspondence to Gerd Heusch.

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J. M. Downey, Mobile, USA served as guest editor for the manuscript and was responsible for all editorial decisions, including the selection of reviewers. The policy applies to all manuscripts with authors from the editor’s institution.

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Skyschally, A., van Caster, P., Iliodromitis, E.K. et al. Ischemic postconditioning: experimental models and protocol algorithms. Basic Res Cardiol 104, 469–483 (2009). https://doi.org/10.1007/s00395-009-0040-4

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