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Laminin-modulierte Entzündungsreaktionen in synovialen Fibroblasten von Rheumapatienten

Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients

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Zusammenfassung

Die hohe Expression von Matrix-Metalloproteinasen (MMP) ist bei rheumatoider Arthritis an der Knorpeldestruktion beteiligt. Wir zeigen einen neuen Weg der entzündlichen Aktivierung von synovialen Fibroblasten, der durch TGF- („transforming growth factor-“)β und Laminin (extrazelluläre Matrix) induziert zu erhöhter Expression der Proteasen MMP-3 und MMP-10 führt und weder Kostimulation durch die zentralen entzündungsfördernden Zytokine IL- (Interleukin-)1β oder TNF- (Tumornekrosefaktor-)α benötigt, noch Signalübertragung durch NF-κB nutzt.

Abstract

Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-β and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-α and IL-1β nor NFkB signalling is needed for this pathway.

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Authors and Affiliations

  1. Zentrum für Medizinische Forschung, Orthopädische Universitätsklinik, Eberhard-Karls-Universität Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Deutschland

    W.K. Aicher

  2. Abteilung für Moleculare Medizin, Orthopädische Universitätsklinik Münster, Münster, Deutschland

    T. Pap

  3. WHO Zentrum für Experimentelle Rheumatologie, Universitätsspital Zürich, Center for Integrative Human Physiology (ZIHP), Zürich, Zürich, Schweiz

    S. Gay

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  1. W.K. Aicher
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  2. T. Pap
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  3. S. Gay
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Correspondence to W.K. Aicher.

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Aicher, W., Pap, T. & Gay, S. Laminin-modulierte Entzündungsreaktionen in synovialen Fibroblasten von Rheumapatienten. Z. Rheumatol. 67, 59–61 (2008). https://doi.org/10.1007/s00393-008-0261-1

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