Zusammenfassung
Das Refeeding-Syndrom ist eine lebensbedrohliche Komplikation, die bei Beginn einer Ernährungstherapie bei mangelernährten Patienten entstehen kann. Bei Kenntnis der Risikofaktoren und der Pathophysiologie kann ihrer Entwicklung wirksam vorgebeugt werden bzw. bei frühzeitiger Erkennung eine wirksame Behandlung erfolgen. Ein langsamer Kostaufbau und die engmaschige Überwachung der Serum-Elektrolyt-Spiegel spielen eine zentrale Rolle. Da das Refeeding-Syndrom wenig bekannt ist und die Symptomatik sehr vielgestaltig sein kann, wird diese Komplikation, insbesondere vor dem Hintergrund der geriatrischen Multimorbidität, sehr häufig nicht erkannt. Die vorliegende Übersicht möchte für die Bedeutung des Refeeding-Syndroms bei der besonderen Risikogruppe der geriatrischen Patienten sensibilisieren.
Abstract
The refeeding syndrome is a life-threatening complication that can occur after initiation of a nutrition therapy in malnourished patients. If the risk factors and pathophysiology are known, the refeeding syndrome can effectively be prevented and treated, if recognized early. A slow increase of food intake and the close monitoring of serum electrolyte levels play an important role. Because the refeeding syndrome is not well known and the symptoms may vary extremely, this complication is poorly recognized, especially against the background of geriatric multimorbidity. This overview is intended to increase the awareness of the refeeding syndrome in the risk group of geriatric patients.
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Discover the latest articles and news from researchers in related subjects, suggested using machine learning.Literatur
National Institute for Health and Care Excellence (NICE) (2006) Nutrition support for adults. In: Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition. NICE, London
Barrett TG, Forsyth JM, Nathavitharana KA, Booth IW (1993) Potentially lethal thiamine deficiency complicating parenteral nutrition in children. Lancet 341:901
Boateng AA, Sriram K, Meguid MM, Crook M (2010) Refeeding syndrome: treatment considerations based on collective analysis of literature case reports. Nutrition 26:156–167
Btaiche IF, Khalidi N (2004) Metabolic complications of parenteral nutrition in adults, part 1. Am J Health Syst Pharm 61:1938–1949
Chernow B, Bamberger S, Stoiko M, Vadnais M, Mills S, Hoellerich V, Warshaw AL (1989) Hypomagnesemia in patients in postoperative intensive care. Chest 95:391–397
Crook MA (2014) Refeeding syndrome: problems with definition and management. Nutrition 30:1448–1455
Crook MA, Hally V, Panteli JV (2001) The importance of the refeeding syndrome. Nutrition 17:632–637
Cumming AD, Farquhar JR, Bouchier IA (1987) Refeeding hypophosphataemia in anorexia nervosa and alcoholism. Br Med J 295:490–491
Deutsche Gesellschaft für Ernährung ÖGfE, Schweizerische Gesellschaft für Ernährungsforschung (2015) Referenzwerte für die Nährstoffzufuhr. Umschau Buchverlag, Neustadt
Dyckner T, Wester PO (1984) Intra-/extracellular shifts of potassium after the administration of Mg in patients with cardiovascular diseases. Magnesium 3:339–345
Fawcett WJ, Haxby EJ, Male DA (1999) Magnesium: physiology and pharmacology. Br J Anaesth 83:302–320
Gonzalez Avila G, Fajardo Rodriguez A, Gonzalez Figueroa E (1996) The incidence of the refeeding syndrome in cancer patients who receive artificial nutritional treatment. Nutr Hosp 11:98–101
Gunther T (1981) Biochemistry and pathobiochemistry of magnesium. Artery 9:167–181
Biesalski HK, Grimm P, Nowitzki-Grimm S (2015) Taschenatlas Ernährung. Thieme, Stuttgart
Hayes JP, Ryan MF, Brazil N, Riordan TO, Walsh JB, Coakley D (1989) Serum hypomagnesaemia in an elderly day-hospital population. Ir Med J 82:117–119
Janett S, Camozzi P, Peeters GG, Lava SA, Simonetti GD, Goeggel Simonetti B, Bianchetti MG, Milani GP (2015) Hypomagnesemia induced by long-term treatment with proton-pump inhibitors. Gastroenterol Res Pract 2015:951768
Johnston SD, Tham TC, Mason M (2008) Death after PEG: results of the national confidential enquiry into patient outcome and death. Gastrointest Endosc 68:223–227
Kagansky N, Levy S, Koren-Morag N, Berger D, Knobler H (2005) Hypophosphataemia in old patients is associated with the refeeding syndrome and reduced survival. J Intern Med 257:461–468
Katzman DK (2005) Medical complications in adolescents with anorexia nervosa: a review of the literature. Int J Eat Disord 37(Suppl):S52–S59
Lubart E, Leibovitz A, Dror Y, Katz E, Segal R (2009) Mortality after nasogastric tube feeding initiation in long-term care elderly with oropharyngeal dysphagia – the contribution of refeeding syndrome. Gerontology 55:393–397
Marik PE, Bedigian MK (1996) Refeeding hypophosphatemia in critically ill patients in an intensive care unit. A prospective study. Arch Surg 131:1043–1047
McLean RM (1994) Magnesium and its therapeutic uses: a review. Am J Med 96:63–76
Mehanna HM, Moledina J, Travis J (2008) Refeeding syndrome: what it is, and how to prevent and treat it. BMJ 336:1495–1498
Mitchell SL, Tetroe JM (2000) Survival after percutaneous endoscopic gastrostomy placement in older persons. J Gerontol A Biol Sci Med Sci 55:M735–M739
Ornstein RM, Golden NH, Jacobson MS, Shenker IR (2003) Hypophosphatemia during nutritional rehabilitation in anorexia nervosa: implications for refeeding and monitoring. J Adolesc Health 32:83–88
Parrish CR (2009) The refeeding syndrome in 2009: prevention is the key to treatment. J Support Oncol 7:20–21
Rio A, Whelan K, Goff L, Reidlinger DP, Smeeton N (2013) Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study. BMJ Open 3(1):e002173
Rohrer S, Dietrich JW (2014) Refeeding syndrome: a review of the literature. Z Gastroenterol 52:593–600
Romanski SA, McMahon MM (1999) Metabolic acidosis and thiamine deficiency. Mayo Clin Proc 74:259–263
Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A (2000) Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 294:1–26
Stanga Z, Brunner A, Leuenberger M, Grimble RF, Shenkin A, Allison SP, Lobo DN (2008) Nutrition in clinical practice-the refeeding syndrome: illustrative cases and guidelines for prevention and treatment. Eur J Clin Nutr 62:687–694
Tsiompanou E, Lucas C, Stroud M (2013) Overfeeding and overhydration in elderly medical patients: lessons from the Liverpool Care Pathway. Clin Med (Lond) 13:248–251
Valentini L, Volkert D, Schütz T, Ockenga J, Pirlich M, Druml W, Schindler K, Ballmer PE, Bischoff SC, Weimann A, Lochs H (2013) Leitlinie der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) – DGEM-Terminologie in der Klinischen Ernährung. Aktuel Ernahrungsmed 38:97–111
Vierling W, Liebscher DH, Micke O, von Ehrlich B, Kisters K (2013) Magnesium deficiency and therapy in cardiac arrhythmias: recommendations of the German Society for Magnesium Research. Dtsch Med Wochenschr 138:1165–1171
Vincent RP, Aylwin SJ, le Roux CW (2009) When the brakes came off: re-feeding oedema after deflation of a gastric band: a case report. Obes Surg 19:1468–1470
Weisinger JR, Bellorin-Font E (1998) Magnesium and phosphorus. Lancet 352:391–396
Whang R, Flink EB, Dyckner T, Wester PO, Aikawa JK, Ryan MP (1985) Magnesium depletion as a cause of refractory potassium repletion. Arch Intern Med 145:1686–1689
Whang R, Oei TO, Aikawa JK, Watanabe A, Vannatta J, Fryer A, Markanich M (1984) Predictors of clinical hypomagnesemia. Hypokalemia, hypophosphatemia, hyponatremia, and hypocalcemia. Arch Intern Med 144:1794–1796
Wirth R, Voss C, Smoliner C, Sieber CC, Bauer JM, Volkert D (2012) Complications and mortality after percutaneous endoscopic gastrostomy in geriatrics: a prospective multicenter observational trial. J Am Med Dir Assoc 13:228–233
Wong ET, Rude RK, Singer FR, Shaw ST Jr. (1983) A high prevalence of hypomagnesemia and hypermagnesemia in hospitalized patients. Am J Clin Pathol 79:348–352
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R. Wirth, R. Diekmann, O. Fleiter, L. Fricke, A. Kreilkamp, M.K. Modreker, C. Marburger, S. Nels, R. Schaefer, H.-P. Willschrei und D. Volkert geben an, dass kein Interessenkonflikt besteht.
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Wirth, R., Diekmann, R., Fleiter, O. et al. Refeeding-Syndrom bei geriatrischen Patienten. Z Gerontol Geriat 51, 34–40 (2018). https://doi.org/10.1007/s00391-016-1160-8
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DOI: https://doi.org/10.1007/s00391-016-1160-8