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Animal models of exocrine pancreatic cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract 

Clinically and biologically relevant animal models are manda-tory to further evaluate both the pathophysiology and novel strategies for diagnosis and treatment of exocrine pancreatic cancer. This review briefly summarizes the features of human pancreatic cancer in order to define requirements for animal models of the disease. The described model systems in rodents include pancreatic cancer induced by chemicals, pancreatic cancer in transgenic, and immunodeficient animals.

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Authors and Affiliations

  1. Department of Surgery, UCLA School of Medicine, Los Angeles, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, CA 90095-6904, USA e-mail: hreber@mednet.ucla.edu Tel.: +1-310-8254976 Fax: +1-310-2062472, , , , , , US

    Hubert G. Hotz, O. Joe Hines & H. A. Reber

  2. Department of Surgery, Benjamin Franklin Medical Center, Freie Universität Berlin, Hindenburgdamm 30, 12200 Berlin, Germany, , , , , , DE

    Thomas Foitzik

Authors
  1. Hubert G. Hotz
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  2. O. Joe Hines
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  3. Thomas Foitzik
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  4. H. A. Reber
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Accepted: 20 April 2000

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Hotz, H., Hines, O., Foitzik, T. et al. Animal models of exocrine pancreatic cancer. Int J Colorect Dis 15, 136–143 (2000). https://doi.org/10.1007/s003840000229

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  • DOI: https://doi.org/10.1007/s003840000229

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