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Risk factors for appendiceal neoplasm and malignancy among patients with acute appendicitis

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Non-operative management of acute uncomplicated appendicitis has shown promising results but might carry the risk of delayed diagnosis of premalignant or malignant appendiceal tumors found by chance in 0.7–2.5% of appendiceal specimen after appendectomy. Purpose of this study was to analyze whether appendiceal tumors are associated with a complicated appendicitis and to determine risk factors for appendiceal neoplasm and malignancy in patients with acute appendicitis.

Methods

We performed a retrospective analysis of 1033 adult patients, who underwent appendectomy for acute appendicitis from 2010 to 2016 at the University hospital Erlangen. Data included patients’ demographics; comorbidities; pre-, intra- and postoperative findings; and histopathological results. Complicated appendicitis was defined in the presence of perforation or abscess.

Results

Appendiceal neoplasm respectively malignancy rate was 2.8% respectively 1.5%. Using univariate analysis, we identified seven risk factors at least for appendiceal neoplasm or malignancy: age, ASA, C-reactive protein, appendiceal diameter, perforation, intraoperative perithyphilitic abscess, and complicated appendicitis. Risk for appendiceal neoplasm or malignancy was 4.4% respectively 2.7% in complicated acute appendicitis compared to 2.0% respectively 1.0% in uncomplicated appendicitis (p = 0.043 respectively p = 0.060). In multivariate analysis, age ≥ 50 years and a diameter of the appendix in the sonography ≥ 13 mm were independent risk factors predicting the presence of appendiceal neoplasm and malignancy.

Conclusion

Among patients with appendicitis, there are relevant risk factors predicting appendiceal tumors, especially age and appendiceal diameter in sonography. But the identified risk factors have a low sensitivity and specificity, so obtaining a confident preoperative diagnosis is challenging.

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Acknowledgments

The present work was performed in partial fulfillment of the requirements for obtaining the degree “Dr. med” for P. Lapins.

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Authors and Affiliations

  1. Department of General and Visceral Surgery, Friedrich-Alexander-University, Krankenhausstraße 12, 91054, Erlangen, Germany

    Maximilian Brunner, Philipp Lapins, Melanie Langheinrich, Justus Baecker, Christian Krautz, Stephan Kersting, Georg F. Weber, Robert Grützmann & Matthias Maak

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  1. Maximilian Brunner
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  2. Philipp Lapins
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  4. Justus Baecker
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Correspondence to Maximilian Brunner.

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Brunner, M., Lapins, P., Langheinrich, M. et al. Risk factors for appendiceal neoplasm and malignancy among patients with acute appendicitis. Int J Colorectal Dis 35, 157–163 (2020). https://doi.org/10.1007/s00384-019-03453-5

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