Abstract
Background
The safety and efficacy of laparoscopic surgery for transverse and descending colon cancer remain controversial. This study aimed to evaluate the short- and long-term outcomes of this procedure.
Methods
We conducted a single-institutional randomized controlled trial. Patients with transverse or descending colon cancer were randomly allocated to receive laparoscopic surgery (LAC) or conventional open surgery (OC). The primary endpoint was the overall complication rate between the two groups. The secondary endpoints were the length of the postoperative hospital stay, the health-related quality of life (HRQOL) score (at 1, 6, and 12 months after surgery), the 5-year relapse-free survival (RFS), and the 5-year overall survival (OS).
Results
Between August 2008 and October 2012, a total of 66 patients were enrolled (33 in the LAC group and 33 in the OC group). The patient characteristics showed no significant differences between the two groups. The complication rates (≥ grade 3) were 6.1% in the LAC group and 12.1% in the OC group (p = 0.392). The length of postoperative stay was not significantly different between the two groups. Regarding the HRQOL, the physical functioning, role physical, bodily pain, social functioning, mental health, and role component summary at 1 month after surgery and the social functioning and mental health at 6 months after surgery were better in the LAC group than in the OC group. The 5-year RFS and OS rates were similar between the LAC and OC groups (RFS 90.5% and 87.3%, respectively, p = 0.752; OS 93.3% and 100.0%, respectively, p = 0.543).
Conclusions
The short- and long-term outcomes of laparoscopic surgery for transverse and descending colon cancer are almost equal to those of open surgery. Laparoscopic resection is a better choice than open surgery for managing this cancer with regard to the short- and mid-term QOL.
Trial registration
ClinicalTrials.gov Identifier: NCT01861691.
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References
Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M, Lacy AM Colon cancer laparoscopic or open resection study group (2005) laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6:477–484
Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, Heath RM, Brown JM, MRC CLASICC trial group (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365:1718–1726
Lacy AM, García-Valdecasas JC, Delgado S, Castells A, Taurá P, Piqué JM, Visa J (2002) Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 359:2224–2229
Clinical Outcomes of Surgical Therapy Study Group, Nelson H, Sargent DJ, Wieand HS, Fleshman J, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W, Ota D (2004) A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 350:2050–2059
Kitano S, Inomata M, Mizusawa J, Katayama H, Watanabe M, Yamamoto S, Ito M, Saito S, Fujii S, Konishi F, Saida Y, Hasegawa H, Akagi T, Sugihara K, Yamaguchi T, Masaki T, Fukunaga Y, Murata K, Okajima M, Moriya Y, Shimada Y (2017) Survival outcomes following laparoscopic versus open D3 dissection for stage II or III colon cancer (JCOG0404): a phase 3, randomised controlled trial. Lancet Gastroenterol Hepatol 2(4):261–268
Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K (2017) Evaluation of lymph flow patterns in splenic flexural colon cancers using laparoscopic real-time indocyanine green fluorescence imaging. Int J Color Dis 32:201–207
Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K (2016) Real-time indocyanine green fluorescence imaging-guided complete mesocolic excision in laparoscopic flexural colon cancer surgery. Dis Colon Rectum 59:701–705
Schlachta CM, Mamazza J, Poulin EC (2007) Are transverse colon cancers suitable for laparoscopic resection? Surg Endosc 21:396–399
Lee YS, Lee IK, Kang WK, Cho HM, Park JK, Oh ST, Kim JG, Kim YH (2008) Surgical and pathological outcome of laparoscopic surgery for transverse colon cancer. Int J Color Dis 23:669–673
Yamamoto S, Fujita S, Akasu T, Yamaguchi T, Moriya Y (2009) Laparoscopic surgery for transverse and descending colon carcinomas has comparable safety to laparoscopic surgery for colon carcinomas at other sites. Dig Surg 26:487–492
Zmora O, Bar-Dayan A, Khaikin M, Lebeydev A, Shabtai M, Ayalon A, Rosin D (2010) Laparoscopic colectomy for transverse colon cancer. Tech Coloproctol 14:25–30
Akiyoshi T, Kuroyanagi H, Fujimoto Y, Konishi T, Ueno M, Oya M, Yamaguchi T (2010) Short-term outcomes of laparoscopic colectomy for transverse colon cancer. J Gastrointest Surg 14:818–823
Yamamoto M, Okuda J, Tanaka K, Kondo K, Tanigawa N, Uchiyama K (2012) Clinical outcomes of laparoscopic surgery for advanced transverse and descending colon cancer: a single-center experience. Surg Endosc 26:1566–1572
Kim HJ, Lee IK, Lee YS, Kang WK, Park JK, Oh ST, Kim JG, Kim YH (2009) A comparative study on the short-term clinicopathologic outcomes of laparoscopic surgery versus conventional open surgery for transverse colon cancer. Surg Endosc 23:1812–1817
Fernández-Cebrián JM, Gil Yonte P, Jimenez-Toscano M, Vega L, Ochando F (2013) Laparoscopic colectomy for transverse colon carcinoma: a surgical challenge but oncologically feasible. Color Dis 15:79–83
Theodoropoulos GE, Karantanos T (2014) Quality of life after laparoscopic colectomy for cancer. JSLS 18:225–235
Maguire A, Sheahan K (2014) Controversies in the pathological assessment of colorectal cancer. World J Gastroenterol 20:9850–9861
National Cancer Institute. Common terminology criteria for adverse events version 4.03. https://evs.nci.nih.gov/ftp1/CTCAE/About.html. Accessed 08 Sep 2018
Fukuhara S, Suzukamo Y (2004) Manual of SF-36v2 Japanese version. Institute for Health Outcomes & Process Evaluation Research, Kyoto
Braga M, Frasson M, Zuliani W, Vignali A, Pecorelli N, Di Carlo V (2010) Randomized clinical trial of laparoscopic versus open left colonic resection. Br J Surg 97:1180–1186
Yamaguchi S, Tashiro J, Araki R, Okuda J, Hanai T, Otsuka K, Saito S, Watanabe M, Sugihara K (2017) Laparoscopic versus open resection for transverse and descending colon cancer: short-term and long-term outcomes of a multicenter retrospective study of 1830 patients. Asian J Endosc Surg 10:268–275
Colon Cancer Laparoscopic or Open Resection Study Group, Buunen M, Veldkamp R, Hop WC, Kuhry E, Jeekel J, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M, Lacy A, Bonjer HJ (2009) Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial. Lancet Oncol 10:44–52
Athanasiou CD, Robinson J, Yiasemidou M, Lockwood S, Markides GA (2017) Laparoscopic vs open approach for transverse colon cancer. A systematic review and meta-analysis of short and long term outcomes. Int J Surg 41:78–85
Jayne DG, Guillou PJ, Thorpe H, Quirke P, Copeland J, Smith AM, Heath RM, Brown JM, UK MRC CLASICC Trial Group (2007) Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol 25:3061–3068
Weeks JC, Nelson H, Gelber S, Sargent D, Schroeder G, Clinical outcomes of surgical therapy (COST) study group (2002) Short-term quality-of-life outcomes following laparoscopic-assisted colectomy vs open colectomy for colon cancer: a randomized trial. JAMA 287:321–328
Braga M, Frasson M, Vignali A, Zuliani W, Civelli V, Di Carlo V (2005) Laparoscopic vs. open colectomy in cancer patients: long-term complications, quality of life, and survival. Dis Colon Rectum 48:2217–2223
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NZ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376
Sprangers MAG, te Velde A, Aaronson NK (1999) The construction and testing of EORTC colorectal cancer-specific quality of life questionnaire module (QLQ-CR38). Eur J Cancer 35:238–247
Psaila J, Bulley SH, Ewings P, Sheffield JP, Kennedy RH (1998) Outcome following laparoscopic resection for colorectal cancer. Br J Surg 85:662–664
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The study protocol was approved by the Ethical Advisory Committee of Yokohama City University School of Medicine before the study was initiated.
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Toritani, K., Watanabe, J., Nakagawa, K. et al. Randomized controlled trial to evaluate laparoscopic versus open surgery in transverse and descending colon cancer patients. Int J Colorectal Dis 34, 1211–1220 (2019). https://doi.org/10.1007/s00384-019-03305-2
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DOI: https://doi.org/10.1007/s00384-019-03305-2