Abstract
Objective
Bactericidal/permeability increasing protein (BPI) gene polymorphisms have been extensively investigated in terms of their associations with inflammatory bowel disease (IBD), with contradictory results. The aim of this meta-analysis was to evaluate associations between BPI gene polymorphisms and the risk of IBD, Crohn’s disease (CD), and ulcerative colitis (UC).
Methods
Eligible studies from PubMed, Embase, and Cochrane library databases were identified.
Results
Ten studies (five CD and five UC) published in five papers were included in this meta-analysis. G645A polymorphism was associated with a decreased risk of UC in allele model, dominant model, and homozygous model.
Conclusions
Our data suggested that BPI G645A polymorphism was associated with a decreased risk of UC; the BPI G645A polymorphism was not associated with the risk of CD.
References
Hendrickson BA, Gokhale R, Cho JH (2002) Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev 15(1):79–94
Schultz H, Weiss JP (2007) The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Clin Chim Acta 384(1–2):12–23
Torok HP, Glas J, Tonenchi L, Mussack T, Folwaczny C (2004) Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the toll-like receptor 4 gene with ulcerative colitis. Clin Immunol 112(1):85–91
Akin H, Tahan G, Ture F, Eren F, Atug O, Tahan V, Hamzaoglu I, Imeryuz N, Tozun N, Hamzaoglu HO (2011) Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease. J Crohns Colitis 5(1):14–18
Can G, Akin H, Ozdemir FT, Can H, Yilmaz B, Eren F, Atug O, Unsal B, Hamzaoglu HO (2015) Bactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population. Saudi J Gastroenterol 21(4):239–244
Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605
Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006) Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63(5):530–538
Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558
Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295(6):676–680
Petermann I, Huebner C, Browning BL, Gearry RB, Barclay ML, Kennedy M, Roberts R, Shelling AN, Philpott M, Han DY, Ferguson LR (2009) Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort. Hum Immunol 70(6):440–446
Walmsley RS, Zhao MH, Hamilton MI, Brownlee A, Chapman P, Pounder RE, Wakefield AJ, Lockwood CM (1997) Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease. Gut 40(1):105–109
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The authors thank all the participants in this study.
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The authors declare that they have no conflict of interest.
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Lijuan Fan, Guoning Fu, and Yuanyuan Ding have contributed equally to this study.
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Fan, L., Fu, G., Ding, Y. et al. Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case–control studies. Int J Colorectal Dis 32, 433–435 (2017). https://doi.org/10.1007/s00384-016-2740-1
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DOI: https://doi.org/10.1007/s00384-016-2740-1