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Growth and risk of adverse neurodevelopmental outcome in infants with congenital surgical anomalies: a systematic review

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Abstract

Survival of infants with congenital anomalies requiring surgical correction has increased dramatically, shifting the focus of clinical care and research toward optimising growth and neurodevelopment.To determine the impact of growth on neurodevelopmental outcomes of infants with congenital surgical anomalies. Studies that reported association of growth with developmental outcomes in infants with congenital anomalies who had surgery, were eligible for inclusion. The search strategy was prospectively drafted, and relevant studies were identified by electronic searches. The Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library 2022, issue 1), MEDLINE and EMBASE from their earliest date to February 2022 were searched. Seven studies met the inclusion criteria. Variability in selection of growth measures, developmental assessment tools and assessment endpoints for neurodevelopment, precluded a meta-analysis. Four studies reported the association between growth and neurodevelopmental outcomes in infants with gastroschisis with two noting adverse outcomes in infants who were small for gestational age. Birthweight, reported in four studies, was not associated with adverse developmental outcomes. Postnatal growth, reported in three studies, was associated with adverse outcome. The data linking growth restriction in infants with congenital surgical anomalies and neurodevelopmental outcome is limited. There is limited published research examining the longitudinal effects of intra- and extra-uterine growth parameters on neurodevelopmental outcomes.

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Data availability

An electronic data collection form was designed, and the following details were collected: Source–name of the study, its author, year of publication Eligibility–confirmation of eligibility or reason for exclusion Methods – study design Summary of the participants and setting Summary of outcomes, including unit of measurement (if relevant) Results–number of participants, attrition rate, summary data Assessment of quality We managed disagreements in eligibility and assessment of quality through discussion.

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Funding

No funding was received for preparation of this manuscript and none of the authors have no financial or non-financial interest.

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Authors and Affiliations

  1. Grace Centre for Newborn Intensive Care, Children’s Hospital at Westmead, Locked Bag 4001, Westmead, NSW, Australia

    Amit Trivedi, Kathryn Browning Carmo & Kristen James-Nunez

  2. Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia

    Amit Trivedi, Kathryn Browning Carmo & Adrienne Gordon

  3. Centre for Newborn Care, Royal Price Alfred Hospital, Camperdown, NSW, Australia

    Adrienne Gordon

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  1. Amit Trivedi
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Contributions

Amit Trivedi conceptualised this systematic review and conducted literature searches with Adrienne Gordon. All authors contributed to the draft of this manuscript, agreed, and approved the submitted manuscript.

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Correspondence to Amit Trivedi.

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Trivedi, A., Browning Carmo, K., James-Nunez, K. et al. Growth and risk of adverse neurodevelopmental outcome in infants with congenital surgical anomalies: a systematic review. Pediatr Surg Int 39, 3 (2023). https://doi.org/10.1007/s00383-022-05305-w

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