Abstract
We describe an unusual clinical presentation of a ganglioglioma in a patient with complex partial seizures. The patient underwent a right temporal lobectomy with subtotal tumor resection at age 15 years, followed by a complete resection 1 year later. Follow-up MRI scan a year later documented recurrence and leptomeningeal dissemination. Another biopsy was performed. Pathological examination revealed similar histology in all three resections, with a ganglioglioma showing no evidence of anaplasia. The tumor exhibited a number of karyotypic abnormalities, notably, a paracentric inversion of chromosome 7. In summary, despite lacking anaplastic features by conventional histological criteria, this ganglioglioma showed an unsusual karyotype and demonstrated radiological evidence of widespread dissemination.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 14 May 1996
Rights and permissions
About this article
Cite this article
Jay, V., Squire, J., Blaser, S. et al. Intracranial and spinal metastases from a ganglioglioma with unusual cytogenetic abnormalities in a patient with complex partial seizures. Child's Nerv Syst 13, 550–555 (1997). https://doi.org/10.1007/s003810050136
Issue Date:
DOI: https://doi.org/10.1007/s003810050136