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Giant fronto-spheno-orbitary juvenile psammomatoid ossifying fibroma: Case report and literature review

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Abstract

Juvenile psammomatoid ossifying fibroma (JPOF) is an osteofibrous neoplasm that originates in the craniofacial skeleton typically during the first three decades of life. JPOFs usually involve the orbit, paranasal sinuses or the jaws. Extensive involvement of the anterior cranial base with compromised visual function is a rare phenomenon. In such clinical context, a definite diagnosis can only be made on the basis of histopathological findings, given the absence of pathognomonic radiological features. Despite being considered a benign entity, JPOFs present a locally aggressive behavior. Therefore, these neoplasms must be included in the differential diagnosis in every patient harboring a skull base osteofibrous lesion, and, once diagnosed, gross total surgical removal should be attempted. In this study, we present our experience in the diagnosis and treatment of a patient diagnosed with a giant JPOF involving the cranial base.

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Authors and Affiliations

  1. Department of Neurosurgery, Ramón y Cajal University Hospital, Madrid, Spain

    Freddy J. Salge-Arrieta, Carlos Vior-Fernández & Rodrigo Carrasco-Moro

  2. Arkansas Neuroscience Institute, Sherwood, AR, USA

    Paul Lee

  3. Department of Pathology, Ramón y Cajal University Hospital, Madrid, Spain

    María E. Reguero-Callejas & Héctor G. Pian-Arias

  4. Department of Neuroradiology, Ramón y Cajal University Hospital, Madrid, Spain

    Juan S. Martínez-San Millán

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  1. Freddy J. Salge-Arrieta
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  2. Carlos Vior-Fernández
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  7. Rodrigo Carrasco-Moro
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Contributions

Conception and design: Salge-Arrieta, Carrasco-Moro. Acquisition of data: Salge-Arrieta, Pian-Arias, Reguero-Callejas, Mártinez-San Millán, Carrasco-Moro. Analysis and interpretation of data: Salge-Arrieta, Carrasco-Moro. Drafting the article: Salge-Arrieta, Vior-Fernández, Lee, Carrasco-Moro. Critically revising the article: Salge-Arrieta, Lee, Carrasco-Moro. Reviewed submitted version of manuscript: Salge-Arrieta, Carrasco-Moro, Pian-Arias, Martínez-San Millán. Administrative/technical/material support: Vior-Fernández, Salge-Arrieta, Carrasco -Moro. Study supervision: Carrasco-Moro.

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Correspondence to Freddy J. Salge-Arrieta.

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Salge-Arrieta, F.J., Vior-Fernández, C., Lee, P. et al. Giant fronto-spheno-orbitary juvenile psammomatoid ossifying fibroma: Case report and literature review. Childs Nerv Syst 40, 939–945 (2024). https://doi.org/10.1007/s00381-023-06206-6

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