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The epidemiologic associations of food availability with national incidence and mortality rates of pediatric central nervous system tumors

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Abstract

Background

The epidemiology of central nervous system (CNS) tumors in pediatric patients worldwide continues to be defined. To date, there has been no evaluation of how national food availability may associate with the incidence and mortality of these tumors. Correspondingly, the aim of this study was to define if such associations exist.

Methods

The most updated incidence and mortality rates of CNS tumors in pediatric patients were abstracted by country from the Global Burden of Disease database. Data regarding food availability parameters were identified and abstracted from the Food Systems Dashboard database. Associations were tested using univariate and multivariate regression analyses.

Results

There were sufficient data in a total of 175 countries worldwide describing the required outcomes. Median incidence and mortality rates across these countries were 1.63 per 100,000 and 0.80 per 100,000, respectively. Higher incidence rates of pediatric CNS tumors were statistically associated with lower availability of fruit and vegetables (P = 0.02), higher average protein supply (P < 0.01), lower share of dietary energy from cereal and roots (P < 0.01), lower supply of meat (P < 0.01), lower supply of nuts and seeds (P < 0.01), lower supply of vegetable oils (P < 0.01), and higher supply of vegetables (P < 0.01). Higher mortality rates due to pediatric CNS tumors were statistically associated with lower availability of fruit and vegetables (P = 0.048), lower supply of fish (P = 0.046), and lower supply of nuts and seeds (P = 0.04). When categorizing countries based on income status, there was a decrease in significant associations found more pronounced in low-middle income countries.

Conclusions

There are many novel associations between national food availability and the incidence and mortality rates of pediatric CNS tumors across the world, which may be more pronounced and divergent in low-middle income countries. A greater understanding is needed to identify what specific components of the significant parameters influence these trends and how public health efforts may best address these associations to improve overall outcomes.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of Miami, Jackson Memorial Hospital, Miami, FL, USA

    Victor M. Lu & Toba N. Niazi

  2. Department of Neurological Surgery, Nicklaus Children’s Hospital, Miami, FL, USA

    Victor M. Lu & Toba N. Niazi

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  1. Victor M. Lu
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Contributions

Victor M. Lu: conceptualization, data curation, writing—original draft preparation. All authors: writing—reviewing and editing, writing—final approval, supervision.

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Correspondence to Victor M. Lu.

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Lu, V.M., Niazi, T.N. The epidemiologic associations of food availability with national incidence and mortality rates of pediatric central nervous system tumors. Childs Nerv Syst 40, 445–451 (2024). https://doi.org/10.1007/s00381-023-06134-5

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  • DOI: https://doi.org/10.1007/s00381-023-06134-5

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