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A unique case of intracranial collision tumor composed of ganglioglioma WHO gr I and supratentorial ependymoma WHO gr III: case-based literature review

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Abstract

Purpose

Intracranial collision tumor is a rare entity that represents the coexistence of two histopathological different tumor types in the same area without histological admixture or an intermediate cell population zone. So far, several cases of collision tumors with ganglioglioma as its component have been reported in the literature, while supratentorial ependymoma has never been reported as a collision tumor component. We are presenting a unique case of collision tumor in patient without previous history of head trauma, neurological surgery, radiotherapy, or phakomatosis.

Methods and results

A 17-year-old male with no previous history of head trauma, neurological surgery, radiotherapy, or phakomatosis was presented to our clinic with grand mal seizure. Brain magnetic resonance imaging with gadolinium contrast was done revealing a contrast-enhancing lesion of right frontal lobe closely related to dura, surrounded by perifocal edema. The patient underwent a gross total tumor resection. Histological examination revealed collision tumor with two distinct components: ganglioglioma and supratentorial ependymoma.

Conclusion

To our best knowledge, no previous reports of collision tumor composed of ganglioglioma and supratentorial ependymoma in a single patient have been reported. We believe that this report could significantly contribute to further surgical practice as well as to treatment decision for these types of collision tumors.

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Authors and Affiliations

  1. Clinic for Neurosurgery, Clinical Center of Serbia, Koste Todorovica 4, Beograd, Serbia

    Aleksandra Nedeljkovic, Rosanda Ilic, Zarko Nedeljkovic, Mihailo Milicevic, Savo Raicevic & Danica Grujicic

  2. Faculty of Medicine, University of Belgrade, Doktora Subotica Starijeg 8, Belgrade, Serbia

    Rosanda Ilic, Mihailo Milicevic & Danica Grujicic

  3. Institut for Pathology, Faculty of Medicine, University of Belgrade, Doktora Subotica starijeg 1, Belgrade, Serbia

    Savo Raicevic

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  1. Aleksandra Nedeljkovic
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Contributions

A. N, R. I., and Z. N. were responsible for study concept and design. A. N, S. R., and Z. N. were responsible for acquisition of data. S. R and A. N. were responsible for figures preparation. A. N., R. I., and Z. N. were responsible for drafting of the manuscript. All authors reviewed the manuscript. S. R. and D. G. were responsible for administrative and technical support. R. I., M. M., and D. G. were responsible for study supervision.

Corresponding author

Correspondence to Aleksandra Nedeljkovic.

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Ethical approval and informed consent

The patient and his parents gave us the approval report for publishing this manuscript. Informed consent was obtained from individual participant included in the study. The ethics committee of the Clinical Center of Serbia approved publication of this manuscript.

Competing interests

On behalf of all authors, the corresponding author states that there is no conflict of interest financial or personal nature. None of the authors have any competing interests in the manuscript. The corresponding author want to point out that the authors presented this case in detail giving correct information about the case.

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Nedeljkovic, A., Ilic, R., Nedeljkovic, Z. et al. A unique case of intracranial collision tumor composed of ganglioglioma WHO gr I and supratentorial ependymoma WHO gr III: case-based literature review. Childs Nerv Syst 39, 2407–2411 (2023). https://doi.org/10.1007/s00381-023-06028-6

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