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Staged Gamma Knife radiosurgery for a rosette-forming glioneuronal tumor of the fourth ventricle: a case report

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Abstract

Background

Rosette-forming glioneuronal tumor (RGNT) is a rare slow-growing neoplasm with mixed glial and neurocytic components. Surgical resection is the mainstay of treatment, whereas the role of adjuvant radiation therapies for residual or recurrent tumors has been poorly investigated.

Case Presentation

We describe the case of a patient with a recurrent fourth ventricular RGNT who was treated with two-staged Gamma Knife radiosurgery (GKRS). GKRS was effective in controlling tumor growth and safe up to seven years from treatment.

Conclusions

This case suggests that GKRS may be a safe and effective treatment for patients with recurrent or residual RGNT.

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Funding

This work was supported by IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano (Milano), Italy.

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Authors and Affiliations

  1. Department of Neurosurgery, IRCCS Humanitas Research Hospital, Rozzano (Mi), Italy

    Andrea Franzini, Piero Picozzi, Giovanni Battista Lasio & Federico Pessina

  2. Department of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20090, Rozzano (Mi), Italy

    Federico Pessina

Authors
  1. Andrea Franzini
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  2. Piero Picozzi
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  3. Giovanni Battista Lasio
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  4. Federico Pessina
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Contributions

Concept and design were done by Franzini and Picozzi. Acquisition of data was done by Franzini. Analysis and interpretation of data were done by Franzini and Lasio. Draft of the article was done by Franzini. Critical revision of the article was done by all authors. The first draft of the manuscript was written by Andrea Franzini, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Andrea Franzini.

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Ethics approval

This retrospective study was approved by the ethics committee of IRCCS Humanitas Research Hospital. The present study was performed in accordance with the ethical standards laid down in the 1964 declaration of Helsinki and its later amendments.

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All authors approved the submission of the present article.

Consent to participate

Informed consent was obtained from the patient described in the present case study.

Conflict of interest

The authors declare no competing interests.

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Franzini, A., Picozzi, P., Lasio, G.B. et al. Staged Gamma Knife radiosurgery for a rosette-forming glioneuronal tumor of the fourth ventricle: a case report. Childs Nerv Syst 39, 3323–3326 (2023). https://doi.org/10.1007/s00381-023-06014-y

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  • DOI: https://doi.org/10.1007/s00381-023-06014-y

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