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Tumor treating fields in pediatric high-grade glioma

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Abstract

Purpose

Tumor treating fields (TTF) are alternating electric fields applied continuously to the scalp. The treatment is approved for both primary and recurrent supratentorial adult glioblastoma but unstudied in children.

Methods

We report a feasibility case series of five pediatric high-grade glioma patients (ages 10–20 years) treated at our institution with TTF along with chemotherapy and/or radiation.

Results

Two patients began therapy at second recurrence and showed progressive disease. Two others were treated upfront after radiation therapy, and both showed partial responses. A fifth patient was treated at first recurrence and also showed a partial response. All five tolerated TTF well without treatment-limiting toxicities.

Conclusions

The tolerability of TTF, combined with the adult data, justify a pediatric clinical trial.

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References

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Authors and Affiliations

  1. Program in Neuro-Oncology, Center for Cancer and Blood Disorders, Children’s Hospital Colorado, 12800 E. 19th Ave. RC1-N, Mail Stop 8302, Aurora, CO, 80045, USA

    Adam L. Green, Jean M. Mulcahy Levy, Rajeev Vibhakar, Molly Hemenway, Jennifer Madden, Nicholas Foreman & Kathleen Dorris

  2. Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave. RC1-N, Mail Stop 8302, Aurora, CO, 80045, USA

    Adam L. Green, Jean M. Mulcahy Levy, Rajeev Vibhakar, Molly Hemenway, Jennifer Madden, Nicholas Foreman & Kathleen Dorris

Authors
  1. Adam L. Green
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  2. Jean M. Mulcahy Levy
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  3. Rajeev Vibhakar
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  4. Molly Hemenway
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  5. Jennifer Madden
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  6. Nicholas Foreman
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  7. Kathleen Dorris
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Corresponding author

Correspondence to Adam L. Green.

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The authors declare that they have no conflict of interest.

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Green, A.L., Mulcahy Levy, J.M., Vibhakar, R. et al. Tumor treating fields in pediatric high-grade glioma. Childs Nerv Syst 33, 1043–1045 (2017). https://doi.org/10.1007/s00381-017-3431-0

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  • DOI: https://doi.org/10.1007/s00381-017-3431-0

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