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Absence of the sagittal suture does not result in scaphocephaly

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Abstract

Purpose

Premature fusion or craniosynostosis of suture(s) of the calvaria is known to result in skull deformation. However, absence of sutures may be interpreted as premature closure of a suture of the calvaria. In the study, the authors investigated skull configuration in skulls found to have isolated absence of the sagittal suture.

Methods

For this study, 400 adult and child skulls from all of the authors’ osteological collections were analyzed.

Results

Of these 400 skulls, three specimens were found to have isolated absence of the sagittal suture (one child and two adults). None of these three skulls were found to have scaphocephaly as a result of the suture absence. No other malformations were found on any specimen. One clinical case is also presented with radiologic findings on the absence of the sagittal suture that also did not have resultant skull malformation.

Conclusions

The authors found that the isolated absence of the sagittal suture does not produce a scaphocephalic skull shape.

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References

  1. Alves JC, Wafae GC, Coelho DDP, Wafae N, Coelho VDA, Pereira E et al (2009) Sagittal suture of the human cranium and the time of closing. Intl J Morphol 27:469–473

    Google Scholar 

  2. Bristol RE, Krieger MD, McComb JG (2011) Normally shaped heads with no sutures, normally shaped heads with abnormal sutures, and abnormally shaped heads with normal sutures. J Craniofac Surg 22:173–177

    Article  PubMed  Google Scholar 

  3. Chandrasekaran S, Shastri D (2012) A study on metopic suture in adult South Indian skull. Intl J Basic Med Sci 1:380–382

    Google Scholar 

  4. Chong S, Mitchell R, Moursi AM, Winnard P, Losken HW, Bradley JP et al (2003) Rescue of coronal suture fusion using transforming growth factor-b3 (Tgf-b3) in rabbits with delayed-onset craniosynostosis. Anat Rec A Discov Mol Cell Evol Biol 274:962–971

    Article  PubMed  Google Scholar 

  5. Coussens AK, Wilkinson CR, Hughes IP, Morris CP, van Daal A, Anderson PJ et al (2007) Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis. BMC Genomics 12:458

    Article  Google Scholar 

  6. Frassanito P, Rocco C (2011) Depicting cranial sutures: a travel into the history. Childs Nerv Syst 27:1181–1183

    Article  PubMed  Google Scholar 

  7. Glass RBJ, Fernbach SK, Norton KI, Choi PS, Naidich TP (2004) The infant skull: a vault of information. RadioGraphics 24:507–522

    Article  PubMed  Google Scholar 

  8. Kinsman SL, Johnston MV (2011) Craniosynostosis. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson Textbook of Pediatrics, 19th edn. Saunders Elsevier, Pennsylvania

    Google Scholar 

  9. Kwan MD, Wan DC, Longaker MT (2005) Craniosynostosis: current treatment and future therapy. Gene Ther Mol Biol 9:423–430

    Google Scholar 

  10. Levine JP, Bradley JP, Roth DA, McCarthy JG, Longaker MT (1998) Studies in cranial suture biology: regional dura mater determines overlying suture biology. Plast Reconstr Surg 101:1441–1447

    Article  PubMed  CAS  Google Scholar 

  11. Madeline LA, Elster AD (1995) Suture closure in the human chondrocranium: CT assessment. Radiology 196:747–756

    PubMed  CAS  Google Scholar 

  12. Mehrara BJ, Mackool RJ, McCarthy JG, Gittes GK, Longaker MT (1998) Immunolocalization of basic fibroblast growth factor and fibroblast growth factor receptor-1 and receptor-2 in rat cranial sutures. Plast Reconstr Surg 102:18051817; discussion 1818–1820

    Google Scholar 

  13. Mehrara BJ, Spector JA, Greenwald JA, Ueno H, Longaker MT (2002) Adenovirus mediated transmission of a dominant negative transforming growth factor-b receptor inhibits in vitro mouse cranial suture fusion. Plast Reconstr Surg 110:506–514

    Article  PubMed  Google Scholar 

  14. Morritt DG, Yeh FJ, Wall SA, Richards PG, Jayamohan J, Johnson D (2010) Management of isolated sagittal synostosis in the absence of scaphocephaly: a series of eight cases. Plast Reconstr Surg 126:572–580

    Article  PubMed  CAS  Google Scholar 

  15. Murlimanju BV, Gupta C, Samiullah D, Prabhu LV, Pai MM, Kumar CG et al (2011) Morphological Investigation of cranial sutures in Indian human adult skulls. Romanian J Morphol Embryol 52:1097–1100

    CAS  Google Scholar 

  16. Opperman LA, Galanis V, Williams AR, Adab K (2002) Transforming growth factor-b3 (Tgf-b3) down-regulates Tgf-b3 receptor type I (Tbr-I) during rescue of cranial sutures from osseous obliteration. Orthod Craniofac Res 5:5–16

    Article  PubMed  CAS  Google Scholar 

  17. Opperman LA, Sweeney TM, Redmon J, Persing JA, Ogle RC (1993) Tissue interactions with underlying dura meter inhibits osseous obliteration of developing cranial sutures Dev Dyn 198:312–322

    CAS  Google Scholar 

  18. Roth DA, Longaker MT, McCarthy JG, Rosen DM, McMullen HF, Levine JP, et al. (1008) Studies in cranial suture biology: Part I. Increased immunoreactivity for transforming growth factor-b (b1, b2, b3) during rat cranial suture fusion. J Bone Miner Res 12:311321

    Google Scholar 

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Conflict of interest

The authors have no conflicts of interest in regard to this study.

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Correspondence to Aaron A. Cohen-Gadol.

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Padmalayam, D., Tubbs, R.S., Loukas, M. et al. Absence of the sagittal suture does not result in scaphocephaly. Childs Nerv Syst 29, 673–677 (2013). https://doi.org/10.1007/s00381-012-2005-4

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  • DOI: https://doi.org/10.1007/s00381-012-2005-4

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