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Stellungnahme der Retinologischen Gesellschaft, der Deutschen Ophthalmologischen Gesellschaft und des Berufsverbands der Augenärzte Deutschlands zur Strahlentherapie bei neovaskulärer altersabhängiger Makuladegeneration

Juni 2015

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Literatur

  1. Archer DB, Gardiner TA (1994) Ionizing radiation and the retina. Curr Opin Ophthalmol 5:59–65

    Article  CAS  PubMed  Google Scholar 

  2. Balaiya S, Malyapa R, Hsi W et al (2012) Evaluation of proton beam radiation sensitivity of proliferating choroidal endothelial and retinal ganglion cells with clonogenic assay. Cutan Ocul Toxicol 31:14–19

    Article  CAS  PubMed  Google Scholar 

  3. Berson AM, Finger PT, Chakravarthy U (1999) Radiation therapy for age-related macular degeneration. Semin Radiat Oncol 9:155–162

    Article  CAS  PubMed  Google Scholar 

  4. Chakravarthy U (2000) Radiotherapy for choroidal neovascularisation of age-related macular degeneration: a fresh perspective. Eye (Lond) 14(Pt 2):151–154

    Article  Google Scholar 

  5. Chakravarthy U, Houston RF, Archer DB (1993) Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study. Br J Ophthalmol 77:265–273

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Deutsche Ophthalmologische G (2015) Die Anti-VEGF-Therapie bei der neovaskularen altersabhangigen Makuladegeneration – therapeutische Strategien: Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbandes der Augenarzte Deutschlands – November 2014. Ophthalmologe 112:237–245

    Article  Google Scholar 

  7. Dugel PU, Bebchuk JD, Nau J et al (2013) Epimacular brachytherapy for neovascular age-related macular degeneration: a randomized, controlled trial (CABERNET). Ophthalmology 120:317–327

    Article  PubMed  Google Scholar 

  8. Evans JR, Sivagnanavel V, Chong V (2010) Radiotherapy for neovascular age-related macular degeneration. Cochrane Database Syst Rev 5:CD004004

    PubMed  Google Scholar 

  9. Finger PT, Berson A, Ng T et al (1999) Ophthalmic plaque radiotherapy for age-related macular degeneration associated with subretinal neovascularization. Am J Ophthalmol 127:170–177

    Article  CAS  PubMed  Google Scholar 

  10. Finger PT, Gelman YP, Berson AM et al (2003) Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study. Br J Ophthalmol 87:1497–1503

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Gertner M, Chell E, Pan KH et al (2010) Stereotactic targeting and dose verification for age-related macular degeneration. Med Phys 37:600–606

    Article  PubMed  Google Scholar 

  12. Gunduz K, Shields CL, Shields JA et al (1999) Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Arch Ophthalmol 117:609–614

    Article  CAS  PubMed  Google Scholar 

  13. Hart PM, Chakravarthy U, Mackenzie G et al (2002) Visual outcomes in the subfoveal radiotherapy study: a randomized controlled trial of teletherapy for age-related macular degeneration. Arch Ophthalmol 120:1029–1038

    Article  CAS  PubMed  Google Scholar 

  14. Hokkanen J, Heikkonen J, Holmberg P (1997) Theoretical calculations of dose distributions for beta-ray eye applicators. Med Phys 24:211–213

    Article  CAS  PubMed  Google Scholar 

  15. Holmes SM, Micka JA, Dewerd LA (2009) Investigation of a 90Sr/90Y source for intra-ocular treatment of wet age-related macular degeneration. Med Phys 36:4370–4378

    Article  CAS  PubMed  Google Scholar 

  16. Holz FG, Engenhart R, Bellmann C et al (1997) Stereotactic radiation therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Front Radiat Ther Oncol 30:238–246

    Article  CAS  PubMed  Google Scholar 

  17. Jaakkola A, Heikkonen J, Tommila P et al (2005) Strontium plaque brachytherapy for exudative age-related macular degeneration: three-year results of a randomized study. Ophthalmology 112:567–573

    Article  PubMed  Google Scholar 

  18. Jaakkola A, Heikkonen J, Tommila P et al (1998) Strontium plaque irradiation of subfoveal neovascular membranes in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 236:24–30

    Article  CAS  PubMed  Google Scholar 

  19. Jackson TL, Chakravarthy U, Kaiser PK et al (2013) Stereotactic radiotherapy for neovascular age-related macular degeneration: 52-week safety and efficacy results of the INTREPID study. Ophthalmology 120:1893–1900

    Article  PubMed  Google Scholar 

  20. Jackson TL, Chakravarthy U, Slakter JS et al (2015) Stereotactic radiotherapy for neovascular age-related macular degeneration: year 2 results of the INTREPID study. Ophthalmology 122:138–145

    Article  PubMed  Google Scholar 

  21. Jackson TL, Dugel PU, Bebchuk JD et al (2013) Epimacular brachytherapy for neovascular age-related macular degeneration (CABERNET): fluorescein angiography and optical coherence tomography. Ophthalmology 120:1597–1603

    Article  PubMed  Google Scholar 

  22. Jackson TL, Shusterman EM, Arnoldussen M et al (2015) Stereotactic radiotherapy for wet age-related macular degeneration (INTREPID): influence of baseline characteristics on clinical response. Retina 35:194–204

    Article  CAS  PubMed  Google Scholar 

  23. Kirwan JF, Constable PH, Murdoch IE et al (2003) Beta irradiation: new uses for an old treatment: a review. Eye (Lond) 17:207–215

    Article  CAS  Google Scholar 

  24. Kumar B, Palimar P (2000) Accelerated radiation retinopathy in diabetes and pregnancy. Eye(Lond) 14(Pt 1):107–108

    Google Scholar 

  25. Mauget-Faysse M, Coquard R, Francais-Maury C et al (2000) Radiothérapie dans la dégénérescence maculaire liée a l’age: facteurs de risque de survenue des complications, prévention et traitement des effets secondaires. J Fr Ophtalmol 23:127–136

    CAS  PubMed  Google Scholar 

  26. Moshfeghi DM, Kaiser PK, Gertner M (2011) Stereotactic low-voltage x-ray irradiation for age-related macular degeneration. Br J Ophthalmol 95:185–188

    Article  PubMed  Google Scholar 

  27. Park SS, Daftari I, Phillips T et al (2012) Three-year follow-up of a pilot study of ranibizumab combined with proton beam irradiation as treatment for exudative age-related macular degeneration. Retina 32:956–966

    Article  PubMed  Google Scholar 

  28. Parsons JT, Bova FJ, Fitzgerald CR et al (1994) Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys 30:765–773

    Article  CAS  PubMed  Google Scholar 

  29. Saric B, Sikic J, Katusic D et al (2001) Brachytherapy-optional treatment for choroidal neovascularization secondary to age-related macular degeneration. Coll Antropol 25 Suppl:89–96

    PubMed  Google Scholar 

  30. Schilling H, Sauerwein W, Friedrichs W et al (1996) Langzeitresultate der Strahlentherapie von Aderhauthämangiomen. Ophthalmologe 93:154–157

    Article  CAS  PubMed  Google Scholar 

  31. Scott TA, Augsburger JJ, Brady LW et al (1991) Low dose ocular irradiation for diffuse choroidal hemangiomas associated with bullous nonrhegmatogenous retinal detachment. Retina 11:389–393

    Article  CAS  PubMed  Google Scholar 

  32. Senan S, Smit EF (2007) Design of clinical trials of radiation combined with antiangiogenic therapy. Oncologist 12:465–477

    Article  CAS  PubMed  Google Scholar 

  33. The Radiation Therapy for Age-Related Macular Degeneration (Rad) Study Group (1999) A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD Study). Radiation Therapy for Age-related Macular Degeneration. Ophthalmology 106:2239–2247

    Article  Google Scholar 

  34. Timke C, Zieher H, Roth A et al (2008) Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy. Clin Cancer Res 14:2210–2219

    Article  CAS  PubMed  Google Scholar 

  35. Zambarakji HJ, Lane AM, Ezra E et al (2006) Proton beam irradiation for neovascular age-related macular degeneration. Ophthalmology 113:2012–2019

    Article  PubMed  Google Scholar 

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Deutsche Ophthalmologische Gesellschaft, Retinologische Gesellschaft und Berufsverbands der Augenärzte Deutschlands geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Diese Stellungnahme erscheint ebenfalls in der Zeitschrift Klinische Monatsblätter für Augenheilkunde, Georg Thieme Verlag, Stuttgart

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Deutsche Ophthalmologische Gesellschaft., Retinologische Gesellschaft. & Berufsverbands der Augenärzte Deutschlands. Stellungnahme der Retinologischen Gesellschaft, der Deutschen Ophthalmologischen Gesellschaft und des Berufsverbands der Augenärzte Deutschlands zur Strahlentherapie bei neovaskulärer altersabhängiger Makuladegeneration. Ophthalmologe 112, 912–916 (2015). https://doi.org/10.1007/s00347-015-0155-y

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