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Short-term and long-term outcomes after resection of thoracic growing teratoma syndrome

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Abstract

Purpose

Thoracic growing teratoma syndrome (TGTS) is a rare disease in patients with germ cell tumors. Other than a few case reports and a limited number of case series, studies of this topic are not available.

Methods

We retrospectively analyzed the data from our patients who received surgery for TGTS between 1999 and 2016. Descriptive statistical analyses were performed to analyze the characteristics of the patients, tumors, and short-term outcomes. Furthermore, the long-term outcomes and survival curves were analyzed using the Kaplan–Meier method.

Results

Twenty-nine patients underwent surgery for TGTS. The median age was 32 years (range: 19–50 years). All patients received cisplatin-based chemotherapy. Many of the patients had multilocalized TGTS (n = 10). The median tumor size was 64.5 mm (range 10-210 mm). In all cases, R0 resection was achieved. The minor morbidity, major morbidity, and mortality rates were 3.4%, 6.9%, and 0%, respectively. Altogether, 28 patients were included in the long-term follow-up analysis, with a median follow-up time of 94 months (13–237 months). The 5-, 10-, and 15-year survival rates were 93%, 93%, and 84%, respectively.

Conclusions

TGTS may occur in multiple localizations and grow to a large tumor size. The resection of TGTS can be performed with low morbidity and mortality rates and is associated with good overall survival after complete resection. Important are an early detection and knowledge of the systemic treatment options by the oncologist and urologist, as well as a thoracic surgeon with a large experience in extended thoracic resections.

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Acknowledgements

This study is part of the doctoral thesis of Kyriaki Chalepaki Ntelli. The authors have no financial relationships, conflicts of interest, informed consent or funding sources to declare.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Agaplesion Markus Krankenhaus Frankfurt, Wilhelm-Epstein-Str. 4, 60431, Frankfurt, Germany

    Stefan Sponholz, Kyriaki Chalepaki Ntelli, Georgios Karaindros, Moritz Schirren & Joachim Schirren

  2. Department of Medical Oncology and Haematology, University Hospital Zurich, Zürich, Switzerland

    Anja Lorch

  3. Department of Urology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany

    Andreas Hiester & Peter Albers

Authors
  1. Stefan Sponholz
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  2. Kyriaki Chalepaki Ntelli
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  3. Georgios Karaindros
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  4. Moritz Schirren
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  5. Anja Lorch
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  6. Andreas Hiester
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  7. Peter Albers
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  8. Joachim Schirren
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Contributions

SS: Project development, Data management, Data analysis, Manuscript writing. CNK: Data management and analysis, Manuscript writing. KG: Data management, Manuscript writing. SM: Project development, Manuscript writing. LA: Data management, Manuscript writing. HA: Data management, Manuscript writing. AP: Data management, Manuscript writing. SJ: Project development, Data management, Manuscript writing.

Corresponding author

Correspondence to Stefan Sponholz.

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Conflict of interest

The authors have no conflicts of interest.

Ethics approval

The Institutional Review Board approved the study (Landesärztekammer Hessen/2019-1437-evBO), which was conducted according to the revised Declaration of Helsinki and the requirements for good clinical practice.

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Sponholz, S., Chalepaki Ntelli, K., Karaindros, G. et al. Short-term and long-term outcomes after resection of thoracic growing teratoma syndrome. World J Urol 39, 2579–2585 (2021). https://doi.org/10.1007/s00345-020-03503-6

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  • DOI: https://doi.org/10.1007/s00345-020-03503-6

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